Postnatal changes in the uncrossed retinal projection of pigmented and albino Syrian hamsters and the effects of monocular enucleation

The Journal of Comparative Neurology
I D ThompsonC E Holt

Abstract

Anterograde and retrograde tracing techniques have been used to study the uncrossed retinal projection in neonatal pigmented and albino Syrian hamsters. The total number of retinal ganglion cells projecting ipsilaterally peaks at postnatal days 2-4 (P2-P4) and declines to adult values by P12. The change in cell numbers has a similar time course in albino and pigmented animals. Although the population of uncrossed cells in the temporal retina of albino hamsters is always less than that in pigmented hamsters, no difference between the colour phases was found for the population of uncrossed cells in nasal retina. Differential cell death also contributes to the adult albino decussation pattern in hamsters: The relative loss of cells from temporal retina in albinos (72%) is greater than that in pigmented animals (56%). The additional loss in albinos does not appear to depend on binocular interactions: The same proportion (30%) of uncrossed cells is "rescued" from death by neonatal monocular enucleation in both colour phases. Flat-mount preparations showing the distribution of uncrossed fibres reveal that a distinct focus of terminals emerges in rostral superior colliculus, which is topographically appropriate for a binocular mapping...Continue Reading

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Citations

Jan 5, 2002·Behavioural Brain Research·Esther G GonzálezMartin J Steinbach
Oct 24, 2007·Brain Research Reviews·Arthur Giraldi-GuimarãesRosalia Mendez-Otero
Nov 17, 2007·The European Journal of Neuroscience·Andrew J TrevelyanIan D Thompson
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Apr 17, 2001·The Journal of Comparative Neurology·P W Land, L Shamalla-Hannah

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