Postnatal colonization with human "infant-type" Bifidobacterium species alters behavior of adult gnotobiotic mice

PloS One
Berkley LukJames Versalovic

Abstract

Accumulating studies have defined a role for the intestinal microbiota in modulation of host behavior. Research using gnotobiotic mice emphasizes that early microbial colonization with a complex microbiota (conventionalization) can rescue some of the behavioral abnormalities observed in mice that grow to adulthood completely devoid of bacteria (germ-free mice). However, the human infant and adult microbiomes vary greatly, and effects of the neonatal microbiome on neurodevelopment are currently not well understood. Microbe-mediated modulation of neural circuit patterning in the brain during neurodevelopment may have significant long-term implications that we are only beginning to appreciate. Modulation of the host central nervous system by the early-life microbiota is predicted to have pervasive and lasting effects on brain function and behavior. We sought to replicate this early microbe-host interaction by colonizing gnotobiotic mice at the neonatal stage with a simplified model of the human infant gut microbiota. This model consortium consisted of four "infant-type" Bifidobacterium species known to be commensal members of the human infant microbiota present in high abundance during postnatal development. Germ-free mice and mic...Continue Reading

References

Oct 1, 1995·Pharmacology, Biochemistry, and Behavior·R J Rodgers, N J Johnson
Sep 4, 2004·Genes, Brain, and Behavior·J J NadlerJ N Crawley
Jun 26, 2007·Applied and Environmental Microbiology·Qiong WangJames R Cole
May 6, 2008·Journal of Psychiatric Research·Lieve DesbonnetTimothy G Dinan
Jan 27, 2009·Applied and Environmental Microbiology·Francesca TurroniMarco Ventura
Feb 21, 2009·Journal of Visualized Experiments : JoVE·Munekazu KomadaTsuyoshi Miyakawa
Jun 11, 2009·Nature Reviews. Neuroscience·Simon P Brooks, Stephen B Dunnett
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Oct 23, 2010·Gut·Mélanie G GareauPhilip M Sherman
Nov 9, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K M NeufeldJ A Foster
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Rochellys Diaz HeijtzSven Pettersson
Oct 13, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P BercikE F Verdu
Mar 6, 2012·Nature Methods·Ben Langmead, Steven L Salzberg
Mar 13, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P BercikE F Verdu
May 19, 2012·PloS One·Francesca TurroniMarco Ventura
Jun 16, 2012·Nature·Tanya YatsunenkoJeffrey I Gordon
Sep 13, 2012·Nature Reviews. Neuroscience·John F Cryan, Timothy G Dinan
Dec 4, 2012·Gut Microbes·Delphine M SaulnierFrancisco Guarner
Feb 7, 2013·Trends in Neurosciences·Jane A Foster, Karen-Anne McVey Neufeld
Mar 14, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R NishinoN Sudo
May 22, 2013·Molecular Psychiatry·L DesbonnetJ F Cryan
Aug 27, 2013·Immunity·Leonid YurkovetskiyAlexander V Chervonsky
Nov 28, 2013·GigaScience·Yoshiki Vázquez-BaezaRob Knight
Nov 30, 2013·Applied Microbiology and Biotechnology·Diana Di GioiaBruno Biavati
Jan 1, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A Ait-BelgnaouiT Tompkins
Feb 14, 2014·Reviews in the Neurosciences·Alexey V ShevelkinMikhail V Pletnikov
May 2, 2014·Nature Communications·Gary FrostJimmy D Bell
Sep 25, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H M SavignacJ F Cryan
Nov 14, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Emeran A MayerKirsten Tillisch
Feb 24, 2015·Biological Psychiatry·Ebere S OgbonnayaOlivia F O'Leary
Feb 24, 2015·FEMS Microbiology Reviews·Hadar NeumanOmry Koren
Mar 22, 2015·Behavioural Brain Research·H M SavignacJ F Cryan
Apr 14, 2015·Brain, Behavior, and Immunity·Lieve DesbonnetJohn F Cryan
Jun 2, 2015·Nature Neuroscience·Daniel ErnyMarco Prinz
Oct 7, 2015·The International Journal of Neuropsychopharmacology·Jane A FosterJohn F Cryan
Feb 3, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Eldin JašarevićTracy L Bale
Feb 26, 2016·The International Journal of Neuropsychopharmacology·Pauline LuczynskiJohn F Cryan

❮ Previous
Next ❯

Citations

Aug 29, 2019·Physiological Reviews·John F CryanTimothy G Dinan
Aug 12, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Q LeyrolleA Nadjar
Mar 15, 2019·Microbiology and Molecular Biology Reviews : MMBR·Janneke ElzingaHauke Smidt
Oct 28, 2019·Frontiers in Microbiology·Melinda A EngevikJames Versalovic
Nov 28, 2019·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Caitlin S M CowanJohn F Cryan
Feb 7, 2020·Gut Pathogens·Lucius Kang Hua HoEvelyn Chung Ning Law
Aug 16, 2019·Gastroenterology Report·Hu HaoHoward S Faden
Nov 4, 2020·Experimental Neurobiology·Tae-Yong ChoiJa Wook Koo
Jan 19, 2021·The European Journal of Neuroscience·Henry T DarchJohn F Cryan
Dec 6, 2019·Frontiers in Neuroendocrinology·Minal JaggarJohn F Cryan
Aug 17, 2020·Cellular and Molecular Gastroenterology and Hepatology·Melinda A EngevikJames Versalovic
Jun 1, 2021·Current Opinion in Immunology·Weronika BarcikFrancesco Papaleo
May 26, 2021·BMC Microbiology·Melinda A EngevikJames Versalovic
Dec 11, 2021·Genes, Brain, and Behavior·Arianna BenedettiFrancesco Papaleo

❮ Previous
Next ❯

Methods Mentioned

BETA
Amplicon-Seq

Software Mentioned

STAMP
Maze
Bowtie2
Graphpad
GraphPad Prism
LotuS with
Ribosomal Database Project Classifier
QIIME
LotuS
ANY

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.