Postnatal conditioning for spreading cortical depression in the rat brain

Brain Research. Developmental Brain Research
Frank RichterW Haschke

Abstract

The cerebral cortex of anaesthetised 2- to 12-day-old rats was superfused with artificial cerebrospinal fluid containing 100 mM acetate substituted for chloride to condition the brain for spreading depression (SD). After such superfusion, the earliest SD-like events were found at day 9 and full blown SD at day 10, whereas in the unconditioned brain the first SD occurred between days 12 and 15. Acetate conditioning of the cerebral cortex may be used to unmask neuronal and glial properties that are hidden in early stages of development.

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Citations

May 18, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Péter HertelendyEszter Farkas
Jun 6, 2003·Journal of Neurophysiology·Frank RichterHans-Georg Schaible
Sep 9, 2000·Journal of Neurophysiology·J Wu, R S Fisher

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