Postnatal development of cholinergic input to the thalamic reticular nucleus of the mouse

The European Journal of Neuroscience
Guela SokhadzeWilliam Guido

Abstract

The thalamic reticular nucleus (TRN), a shell-like structure comprised of GABAergic neurons, gates signal transmission between thalamus and cortex. While TRN is innervated by axon collaterals of thalamocortical and corticothalamic neurons, other ascending projections modulate activity during different behavioral states such as attention, arousal, and sleep-wake cycles. One of the largest arise from cholinergic neurons of the basal forebrain and brainstem. Despite its integral role, little is known about how or when cholinergic innervation and synapse formation occurs. We utilized genetically modified mice, which selectively express fluorescent protein and/or channelrhodopsin-2 in cholinergic neurons, to visualize and stimulate cholinergic afferents in the developing TRN. Cholinergic innervation of TRN follows a ventral-to-dorsal progression, with nonvisual sensory sectors receiving input during week 1, and the visual sector during week 2. By week 3, the density of cholinergic fibers increases throughout TRN and forms a reticular profile. Functional patterns of connectivity between cholinergic fibers and TRN neurons progress in a similar manner, with weak excitatory nicotinic responses appearing in nonvisual sectors near the end...Continue Reading

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Citations

Apr 11, 2019·The European Journal of Neuroscience·Carol A Mason, S Murray Sherman
May 19, 2020·The Journal of Comparative Neurology·Luis PuellesJohn L R Rubenstein
Oct 7, 2018·Molecular Neurobiology·Tamara HeermannSabine M Hölter
Jul 23, 2021·Neuron·Francisco J MartiniGuillermina López-Bendito
Sep 22, 2021·The Journal of Comparative Neurology·Guela SokhadzeAaron W McGee

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