Postnatal development of lymphatic vasculature in the brain meninges

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Rebecca M IzenYoh-Suke Mukouyama

Abstract

Traditionally, the central nervous system (CNS) has been viewed as an immune-privileged environment with no lymphatic vessels. This view was partially overturned by the discovery of lymphatic vessels in the dural membrane that surrounds the brain, in contact with the interior surface of the skull. We here examine the distribution and developmental timing of these lymphatic vessels. Using the Prox1-GFP BAC transgenic reporter and immunostaining with antibodies to lymphatic markers LYVE-1, Prox1, and Podoplanin, we have carried out whole-mount imaging of dural lymphatic vasculature at postnatal stages. We have found that between birth and postnatal day (P) 13, lymphatic vessels extend alongside dural blood vessels from the side of the skull toward the midline. Between P13 and P20, lymphatic vessels along the transverse sinuses reach the superior sagittal sinus (SSS) and extend along the SSS toward the olfactory bulb. Compared with the embryonic developmental timing of lymphatic vessels in other tissues, e.g. skin, dural lymphatic vessel development is dramatically delayed. This study provides useful anatomical data for continuing investigations of the fundamental mechanisms that underlie dural lymphatic vessel development. Develo...Continue Reading

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Citations

Mar 21, 2019·Animal Models and Experimental Medicine·Zhuo LiChuan Qin
Jun 19, 2019·Neurosurgical Review·Ryota TamuraMasahiro Toda
Jan 8, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Satoshi TsutsumiYukimasa Yasumoto
Jan 30, 2020·Frontiers in Immunology·László BálintZoltán Jakus
Jul 11, 2020·Science·Tatiana V Petrova, Gou Young Koh
May 5, 2020·Neuroscience Insights·Korri S HershenhouseKetan M Patel
Nov 3, 2020·Circulation Research·Daniel CastranovaBrant M Weinstein
Jan 20, 2021·Nature Reviews. Cardiology·Konstantinos KlaourakisPaul R Riley
Apr 8, 2021·Angiogenesis·Daniyal J JafreeChristiana Ruhrberg
May 18, 2021·Frontiers in Pharmacology·Sofia Pereira das NevesSandro Da Mesquita
Jul 20, 2021·Frontiers in Cellular Neuroscience·Julia DerkJulie A Siegenthaler

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