Postnatal Development of Microglia-Like Cells in Mouse Cochlea

Neural Plasticity
Penghui ChenHao Wu

Abstract

Microglial cells are involved in surveillance and cleaning of the central nervous system. Recently, microglial-like cells (MLC) have been found in an adult cochlea and investigated for their role in cochlear inflammation. The presence and potential roles of MLCs during the development of the cochlea, however, remain unclear. In this study, immunostaining was performed using the MLC-specific marker IBA1 to characterize the presence, distribution, and morphology of MLCs in the developing cochlea. From P0 to P14, MLCs were present in a variety of cochlear regions including the modiolus, spiral lamina, spiral ganglion, spiral ligament, and the organ of Corti. Interestingly, the overall number of MLCs in a mouse cochlea steadily increased since P0, peaks at P5, then gradually decreased from P5 to P14. In the spiral ligament, the distribution of the MLCs trends to shift from the type I/II fibrocyte-rich regions to the type III/IV fibrocyte-rich regions during the course of cochlear development, accompanied by the morphological changes of MLCs from the amoeboid, activated form to the ramified, quiescent form. Our results suggested that MLCs experience drastic morphological and distributional changes during postnatal cochlear developme...Continue Reading

References

Aug 13, 1998·The Journal of Comparative Neurology·S A BhaveM D Coltrera
Mar 16, 2006·The Journal of Comparative Neurology·Hainan LangBradley A Schulte
May 15, 2007·Journal of Neuroscience Research·Sabine LadrechMarc Lenoir
Dec 19, 2007·The Journal of Comparative Neurology·Eisuke SatoKeiko Hirose
Aug 18, 2009·Current Opinion in Neurobiology·Michael C Kelly, Ping Chen
Jan 23, 2014·Journal of Neuroinflammation·Susana G Torres-PlatasNaguib Mechawar
Apr 10, 2014·Nature Reviews. Neuroscience·Marco Prinz, Josef Priller
Oct 21, 2015·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jennifer T O'MalleyMichael J McKenna
Nov 8, 2017·Molecular and Cellular Neurosciences·G M SeigelR Salvi

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Citations

Aug 18, 2020·Neural Plasticity·Linjun ChenShiming Yang

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