Postnatal development of protein P-38 ('synaptophysin') immunoreactivity in pontine and medullary gustatory zones of rat

Brain Research. Developmental Brain Research
P S Lasiter, D L Kachele

Abstract

Neurons located in gustatory zones of the nucleus of the solitary tract (NST) and parabrachial nucleus (PBN) exhibit extensive morphological development during the first 5-7 weeks of rat's postnatal life. The present study examined the time course for development of protein P-38 ('synaptophysin'), a specific integral membrane glycoprotien of clear synaptic vesicles, in the rostral NST and PBN. Results show that volumetric fractions of P-38 immunoreactions increase in the NST from P1 to P10, and are adult-like in the NST after approximately P11. In contrast, volumetric fractions of P-38 immunoreactivity increase in the PBN between approximately P11 and P30. Because we have previously demonstrated that dendritic growth in the rostral gustatory NST precedes dendritic growth in the PBN, these results confirm that maturation of both presynaptic and postsynaptic constituents of brainstem gustatory relays develop in a temporally sequential manner. Relationships between neurological development of brainstem gustatory relays and the ontogeny of taste-guided responses are discussed.

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Citations

Oct 27, 1995·Brain Research. Developmental Brain Research·M KnipperH P Zenner
Nov 21, 1995·Brain Research. Developmental Brain Research·P S Lasiter, B B Bulcourf
May 1, 1992·Neurobiology of Aging·W G HonerP Davies
Jun 16, 2000·Physiology & Behavior·P M Di Lorenzo
Jul 27, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·W L HeckL Schweitzer
May 6, 1998·Journal of Anatomy·L Scott, M E Atkinson
Aug 1, 1997·The European Journal of Neuroscience·A Vincent, F Tell
Sep 27, 2015·Frontiers in Neuroendocrinology·Amanda E Elson, Richard B Simerly
Jun 14, 2006·Developmental Psychobiology·Linda Rinaman
Sep 1, 1991·The American Journal of Anatomy·D GanchrowR S Goldstein

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