PMID: 490250Nov 1, 1979Paper

Postnatal development of renal sodium handling in premature infants

The Journal of Pediatrics
E SulyokI F Csaba

Abstract

To estimate the contribution of the specific defect in proximal and distal tubular reabsorption of sodium to renal salt wasting, fractional sodium excretion, distal tubular sodium delivery, and distal tubular sodium reabsorption were determined in 11 healthy premature infants. The study was performed on the seventh day and at weekly intervals thereafter up to the sixth week of life. Sodium clearance and fractional sodium excretion decreased significantly with increasing postnatal age (P less than 0.001). There was no significant alteration in either osmolar or free-water clearances. Distal tubular sodium delivery steadily decreased from 4.96 +/- 0.66 (mean +/- SE) in the first week to 3.3 +/- 0.41 ml/minute/dl GFR in the sixth week of life (P less than 0.05). Distal tubular sodium reabsorption was 69.5 +/- 2.36% in the first week, then rose significantly to reach a value of 83.7 +/- 1.85% in the second week (P less than 0.001) and remained practically unchanged thereafter. It is suggested that the rapid improvement of distal tubular sodium reabsorption in premature infants might result from forced stimulation by the excessively activated renin-angiotensin-aldosterone system.

References

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Citations

Apr 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J al-DahanG B Haycock
Jan 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·G B Haycock, A Aperia
May 1, 1994·Indian Journal of Pediatrics·R P VermaD Vidyasagar
Dec 1, 1986·The Journal of Pediatrics·T TulassayE Sulyok
May 21, 2003·Journal of Paediatrics and Child Health·D Bourchier
Apr 25, 2001·Kidney International·R L Chevalier
May 1, 1983·Archives of Disease in Childhood·J Al-DahhanL Stimmler
May 1, 1983·Archives of Disease in Childhood·J Al-DahhanL Stimmler
May 1, 1984·Archives of Disease in Childhood·L ReesM L Forsling
Feb 1, 1985·Archives of Disease in Childhood·E Sulyok
Jan 15, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·G HartnollN Modi
May 20, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vesna StojanovićAleksandra Doronjski
Sep 1, 1985·Early Human Development·M G Coulthard
Aug 1, 1989·The Journal of Pediatrics·S G Shaffer, V M Meade
Mar 1, 1988·Acta paediatrica Scandinavica·M VanpeéA Aperia
May 1, 1987·Acta paediatrica Scandinavica·P Herin, R Zetterström
Jul 28, 2017·Archives of Disease in Childhood. Fetal and Neonatal Edition·Simon TraversEric Pussard
Feb 1, 1985·Archives of Disease in Childhood·S Ozsoylu
Nov 1, 1984·Acta paediatrica Scandinavica·P SujovZ Hochberg
Jun 6, 2014·American Journal of Physiology. Renal Physiology·Lina GubhajuM Jane Black
Jun 28, 2015·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Qing WangYanhong Li
Apr 1, 1982·Kidney International·A Spitzer

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