Postnatal development of the cholecystokinin innervation of monkey prefrontal cortex

The Journal of Comparative Neurology
K M Oeth, D A Lewis

Abstract

Although the structure and function of primate prefrontal cortex undergo substantial modifications during postnatal development, relatively little is known about the maturation of neurotransmitter systems in these cortical regions. In the primate brain, cholecystokinin is present in the greatest concentrations in prefrontal regions. Thus, in this study, we used immunohistochemical techniques to investigate the postnatal development of the cholecystokinin innervation of monkey prefrontal cortex. In animals aged 4 days through adult, cholecystokinin immunoreactivity was present in nonpyramidal neurons that appeared to represent at least two distinct cell types. The most common type was a vertically oval bitufted neuron, located in layers II-superficial III, which typically had a radially descending axon that gave rise to short collaterals in layer IV. Another frequently observed cell type was a larger multipolar neuron located in the superficial half of layer III. The axon of these neurons branched locally in the vicinity of the cell body. The greatest density of cholecystokinin-containing neurons and processes was present in monkeys less than 1 month of age. The density of immunoreactive structures in every prefrontal region the...Continue Reading

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Citations

Mar 1, 1997·Journal of Psychiatric Research·S E BachusJ E Kleinman
Jun 18, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stephen M EgganDavid A Lewis
Jan 30, 2003·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Christopher J Machado, Jocelyne Bachevalier
Jan 6, 2012·The Journal of Physiology·Allison A Curley, David A Lewis
Aug 28, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Monica Beneyto, David A Lewis
Oct 7, 2015·Frontiers in Neuroanatomy·Paul D WhissellJun Chul Kim

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