Postnatal development of the cholecystokinin innervation of monkey prefrontal cortex

The Journal of Comparative Neurology
K M Oeth, D A Lewis


Although the structure and function of primate prefrontal cortex undergo substantial modifications during postnatal development, relatively little is known about the maturation of neurotransmitter systems in these cortical regions. In the primate brain, cholecystokinin is present in the greatest concentrations in prefrontal regions. Thus, in this study, we used immunohistochemical techniques to investigate the postnatal development of the cholecystokinin innervation of monkey prefrontal cortex. In animals aged 4 days through adult, cholecystokinin immunoreactivity was present in nonpyramidal neurons that appeared to represent at least two distinct cell types. The most common type was a vertically oval bitufted neuron, located in layers II-superficial III, which typically had a radially descending axon that gave rise to short collaterals in layer IV. Another frequently observed cell type was a larger multipolar neuron located in the superficial half of layer III. The axon of these neurons branched locally in the vicinity of the cell body. The greatest density of cholecystokinin-containing neurons and processes was present in monkeys less than 1 month of age. The density of immunoreactive structures in every prefrontal region the...Continue Reading


Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M PingetR S Yalow
Jan 1, 1992·Progress in Neurobiology·M Hayashi
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M S LidowP Rakic
Nov 1, 1990·The Journal of Comparative Neurology·K M Oeth, D A Lewis
Nov 1, 1991·The Journal of Comparative Neurology·H BarbasC R Dermon
Jan 1, 1990·Progress in Brain Research·L MrzljakM Judás
Oct 22, 1990·The Journal of Comparative Neurology·H Barbas, J De Olmos
Aug 15, 1989·The Journal of Comparative Neurology·H Barbas, D N Pandya
Jan 1, 1985·Journal of Neurochemistry·J F Rehfeld
Mar 24, 1987·Brain Research·K Gysling, M C Beinfeld
Nov 1, 1988·Brain Research. Developmental Brain Research·M F BealD L Price
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C RoseJ C Schwartz
May 1, 1986·Journal of Clinical Periodontology·N W Chilton, J L Fleiss
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S H HendryM C Beinfeld
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S H HendryP C Emson
May 1, 1981·The Journal of Comparative Neurology·L J PorrinoP S Goldman-Rakic
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Aug 1, 1981·The Journal of Clinical Endocrinology and Metabolism·F L GeolaW W Tourtellotte
Dec 20, 1984·The Journal of Comparative Neurology·D G Amaral, J L Price
Mar 1, 1981·Journal of Neurochemistry·N R GoltermannN J Christensen
Apr 1, 1982·Journal of Neurochemistry·P C EmsonM N Rossor

❮ Previous
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