Postnatal development of the endbulb of held in congenitally deaf cats.

Frontiers in Neuroanatomy
Christa A BakerD K Ryugo

Abstract

The endbulbs of Held are formed by the ascending branches of myelinated auditory nerve fibers and represent one of the largest synaptic endings in the brain. Normally, these endings are highly branched and each can form up to 1000 dome-shaped synapses. The deaf white cat is a model of congenital deafness involving a type of cochleosaccular degeneration that mimics the Scheibe deformity in humans. Endbulbs of mature deaf white cats exhibit reduced branching, hypertrophy of postsynaptic densities (PSDs), and changes in synaptic vesicle density. Because cats are essentially deaf at birth, we sought to determine if the progression of brain abnormalities was linked in time to the failure of normal hearing development. The rationale was that the lack of sound-evoked activity would trigger pathologic change in deaf kittens. The cochleae of deaf cats did not exhibit abnormal morphology at birth. After the first postnatal week, however, the presence of a collapsed scala media signaled the difference between deaf and hearing cats. By working backwards in age, endbulbs of deaf cats expressed flattened and elongated PSDs and increased synaptic vesicle density as compared to normal endbulbs. These differences are present at birth in some wh...Continue Reading

Citations

Feb 12, 2011·Hearing Research·Jahn N O'NeilDavid K Ryugo
Jan 13, 2015·Hearing Research·Mandy SonntagMarkus Morawski
Jun 21, 2012·Journal of Neuroscience Research·Tetsuji SekiyaBarbara Canlon
Jan 13, 2012·The Journal of Comparative Neurology·Natasha N Tirko, David K Ryugo
Jan 21, 2014·The EMBO Journal·Alejandro Mendoza SchulzTobias Moser
Feb 11, 2014·Hearing Research·Wei-Ming Yu, Lisa V Goodrich
Jul 31, 2016·Hearing Research·Catherine J ConnellyMichael A Muniak
Dec 13, 2012·Brain : a Journal of Neurology·Andrej KralJochen Tillein

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