PMID: 7538055Feb 16, 1995Paper

Postnatal development of the substance P-, neuropeptide Y- and serotonin-containing fibers in the rat suprachiasmatic nucleus in relation to development of the retino-hypothalamic projection

Brain Research. Developmental Brain Research
K TakatsujiM Tohyama

Abstract

The suprachiasmatic nucleus (SCN) in the hypothalamus controls many of the circadian rhythms in mammalian species. In the present study, we investigated the development of substance P (SP)-, neuropeptide Y (NPY)- and serotonin (5-hydroxytryptamine, 5-HT)-immunoreactive fibers in the rat SCN and the development of the retino-hypothalamic tract using cholera toxin beta subunits (CTB), in order to understand which parts of the SCN participate in diurnal rhythm regulation and entrainment. In newborn rats, SP-, NPY- and 5-HT-immunoreactive fibers were scarcely detected in the SCN. The number of SP-immunoreactive fibers gradually increased between postnatal days (P) 15 and 30. At P30, the distribution pattern of SP-immunoreactive fibers in the SCN was similar to that in the adult rat. The number of NPY- and 5-HT-immunoreactive fibers increased greatly between P10 and P15, and the increase in NPY- and 5-HT-immunoreactive fibers continued until P20. CTB was injected into the unilateral eyeball of the rat at various postnatal stages. In neonates, several labeled retinal fibers already existed in the ventral part and ventro-lateral edge of the SCN. The number and density of labeled retinal fibers in the SCN gradually increased between P1...Continue Reading

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Citations

Sep 14, 2012·Psychopharmacology·Veronika KiryanovaMichael C Antle
May 26, 2015·Frontiers in Systems Neuroscience·Joseph L Bedont, Seth Blackshaw
Jan 25, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M M Canal-CorretgerA Díez-Noguera
Jan 7, 2003·The Journal of Biological Chemistry·Kentaro Oh-hashiMasaki Tanaka
Aug 5, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C A MaguireV M Navarro
Apr 10, 2021·Frontiers in Neuroscience·Arthur H Cheng, Hai-Ying Mary Cheng

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