PMID: 6408215Jun 1, 1983Paper

Postnatal developmental pattern of thyrotrophin releasing hormone-degrading activity in rat plasma, hypothalamus and liver: role of tri-iodothyronine

The Journal of Endocrinology
S Aratan-SpireP Czernichow

Abstract

Thyrotrophin releasing hormone-degrading activity (TRH-DA) is present in plasma, hypothalamus, pituitary gland, liver and kidney of adults of several species. Each of these tissues contains more than one TRH-degrading enzyme but only one, pyroglutamate aminopeptidase, isolated from the blood, is a TRH-specific enzyme. The aim of this study was to describe the developmental pattern of TRH-DA in the plasma, hypothalamus and liver and the role of tri-iodothyronine (T3) in the development of TRH-DA in the rat. Based on the hypothesis that thyroid hormones stimulate plasma TRH-DA in adult rats, degradation of TRH was studied in hypo- or hyperthyroid rats induced by 6-n-propyl-2-thiouracil or T3 respectively. Tritiated TRH was incubated with plasma and homogenates of hypothalamus or liver. After separation of degradation products by thin-layer chromatography, the amount of degraded [3H]TRH (pmol/50 microliters plasma or homogenate) was taken as a comparative index of TRH-DA. Plasma TRH-DA was not detectable before day 9 while hypothalamic and hepatic TRH-DA was already active at birth. Furthermore, the maturation pattern of total TRH-DA was different in plasma compared with other tissues and T3 appeared to play a significant role in ...Continue Reading

Citations

Jul 1, 1994·The International Journal of Neuroscience·J M De GandariasL Casis
May 16, 1990·Biochemical and Biophysical Research Communications·S Aratan-SpireA H Tashjian
Aug 1, 1985·Journal of Endocrinological Investigation·I GerendaiA Tixier-Vidal
Dec 1, 1990·The American Journal of Physiology·Y FuseD A Fisher
Jan 1, 1991·The American Journal of Physiology·D H PolkD A Fisher

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