Postnatal environment overrides genetic and prenatal factors influencing offspring obesity and insulin resistance

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Judith N GorskiBarry E Levin

Abstract

There is growing evidence that the postnatal environment can have a major impact on the development of obesity and insulin resistance in offspring. We postulated that cross-fostering obesity-prone offspring to lean, obesity-resistant dams would ameliorate their development of obesity and insulin resistance, while fostering lean offspring to genetically obese dams would lead them to develop obesity and insulin resistance as adults. We found that obesity-prone pups cross-fostered to obesity-resistant dams remained obese but did improve their insulin sensitivity as adults. In contrast, obesity-resistant pups cross-fostered to genetically obese dams showed a diet-induced increase in adiposity, reduced insulin sensitivity, and associated changes in hypothalamic neuropeptide, insulin, and leptin receptors, which might have contributed to their metabolic defects. There was a selective increase in insulin levels and differences in fatty acid composition of obese dam milk which might have contributed to the increased adiposity, insulin resistance, and hypothalamic changes in obesity-resistant cross-fostered offspring. These results demonstrate that postnatal factors can overcome both genetic predisposition and prenatal factors in determ...Continue Reading

References

Jul 1, 1979·Pharmacology, Biochemistry, and Behavior·B E Levin, A C Sullivan
Apr 1, 1989·Journal of the American College of Nutrition·L Jovanovic-PetersonC M Peterson
Jun 1, 1985·Metabolism: Clinical and Experimental·J TriscariA C Sullivan
Nov 1, 1984·Peptides·A S Levine, J E Morley
Dec 1, 1993·Endocrine Reviews·C E GrosvenorC R Baumrucker
Jan 1, 1993·Annual Review of Nutrition·C Bouchard, L Pérusse
Aug 1, 1997·The American Journal of Physiology·B E LevinR E Keesey
Jul 17, 1998·Metabolism: Clinical and Experimental·T HarderG Dörner
Oct 2, 1998·The American Journal of Physiology·B E Levin, E Govek
Apr 29, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A PlagemannG Dörner
May 20, 1999·International Review of Cytology·D M WeisenhornB H Wainer
Apr 25, 2000·Hypertension·A D DobrianT J Lauterio
Sep 23, 2000·American Journal of Physiology. Endocrinology and Metabolism·M ZiotopoulouJ S Flier
Oct 24, 2000·Genome Research·P C ReifsnyderE H Leiter
Jun 5, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·UNKNOWN World Medical Association General Assembly.
May 11, 2002·The Proceedings of the Nutrition Society·Patricia E Wainwright
May 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Hongqin WangXu-Feng Huang
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·UNKNOWN World Medical Association, UNKNOWN American Physiological Society
Oct 3, 2002·Journal of Neurochemistry·Ian C G WeaverMichael J Meaney
Oct 12, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Barry E Levin, Ambrose A Dunn-Meynell
Feb 1, 2003·Neuroscience·K L GroveM S Smith
May 31, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew R Ricci, Barry E Levin
Jul 17, 2003·American Journal of Physiology. Endocrinology and Metabolism·Barry E LevinDavid E Cummings
Sep 6, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Barry E LevinWilliam A Banks
Nov 1, 1957·The Journal of Endocrinology·G C KENNEDY

❮ Previous
Next ❯

Citations

Jul 4, 2012·Journal of Mammary Gland Biology and Neoplasia·Margaret C NevillePeter Williamson
Mar 24, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Z Y Ong, B S Muhlhausler
May 23, 2012·Clinical and Experimental Pharmacology & Physiology·Maria E D'AlessandroAdriana Chicco
Jan 20, 2011·Journal of Paediatrics and Child Health·Matthew W KempJohn P Newnham
Sep 30, 2009·Acta Physiologica·E N MakarovaN M Bazhan
Aug 28, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christelle Le FollBarry E Levin
Jan 2, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Boman G IraniBarry E Levin
Aug 24, 2011·Annals of Nutrition & Metabolism·Mulchand S Patel, Malathi Srinivasan
Jun 17, 2008·Endocrinology·Boman G IraniBarry E Levin
Jun 23, 2009·Journal of Endocrinological Investigation·F RosiD Magistrelli
Jan 24, 2014·Journal of Diabetes Research·Xinli JiangYan Liu
Sep 27, 2014·Mediators of Inflammation·Hellen Barbosa Farias SilvaVanessa Cristina Arantes
Jun 16, 2012·International Journal of Pediatrics·Kyung E RheeJeanne McCaffery
Feb 14, 2016·Physiology & Behavior·Sayuri KojimaLinda Rinaman
Jan 1, 2016·Behavioural Brain Research·Jessica R GugusheffBeverly S Muhlhausler
Sep 18, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Andreas PlagemannJens H Stupin
Jan 7, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·D SimarM J Morris
Aug 25, 2009·Physiology & Behavior·Denise R LabelleLoretta M Flanagan-Cato
Dec 16, 2006·Experimental Physiology·P D Taylor, L Poston
Apr 15, 2009·Developmental Psychobiology·Mariana SchroederAron Weller
May 31, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·B L HeitmannM S Westerterp-Plantenga
Mar 19, 2014·Birth·Maria João FonsecaAna Cristina Santos
Sep 17, 2014·Acta Obstetricia Et Gynecologica Scandinavica·Jens H NielsenNils Billestrup
Mar 22, 2016·Developmental Psychobiology·Caroline M BodiElizabeth M Byrnes
Aug 20, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Yik Lung ChanHui Chen
Jun 9, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M A VithayathilB S Muhlhausler
Sep 18, 2013·Physiology & Behavior·Anna Voznesenskaya, Michael G Tordoff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.