Postnatal epithelial growth of the small intestine in the rat occurs by both crypt fission and crypt hyperplasia.

Digestive Diseases and Sciences
Adrian G CumminsFiona M Thompson

Abstract

Studies of growth of the small intestine have largely concentrated on crypt hyperplasia rather than crypt fission. The aim of this study was to investigate quantitatively both crypt fission and crypt hyperplasia. DAxPVG/c rats were killed at 7, 11, 14, 17, 19, 21, 25, 55, and 72-73 days of life. Samples of jejunum at one third of the intestinal length were taken for morphometry (villous area, crypt area, percentage of bifid crypts, and crypt mitotic count) by microdissection. Growth factors and their receptors were assessed by oligonucleotide microarray. Crypt fission was 10.5%, 5.2%, and 1.5% at days 11, 25, and 72-73 of life, respectively. Crypt hyperplasia increased from day 21. No conventional growth factor was identified during crypt fission. We conclude that crypt fission contributes to growth of the small intestine prior to weaning and crypt hyperplasia to growth after weaning.

References

May 1, 1985·Cell and Tissue Kinetics·W H St Clair, J W Osborne
Mar 1, 1994·Journal of Clinical Immunology·A G CumminsD M Roberton
Jul 15, 1997·The Journal of Surgical Research·Y KatoM Z Schwartz
May 20, 1998·Journal of Pediatric Gastroenterology and Nutrition·F M ThompsonA G Cummins
Jun 6, 1998·The Journal of Pathology·R J PlayfordR A Goodlad
Feb 25, 1999·Gastroenterology·R K MontgomeryR J Grand
Nov 30, 1999·Journal of Pediatric Gastroenterology and Nutrition·M MasjediA G Cummins
Jun 7, 2002·Journal of Pediatric Gastroenterology and Nutrition·Chie HiraiSatoshi Kusuda
Jul 10, 2003·Gastroenterology·Christopher R ErwinBrad W Warner
Jul 17, 2003·Genes & Development·Daniel PintoHans Clevers
Dec 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Frank KuhnertCalvin J Kuo
Apr 16, 2004·The Journal of Biological Chemistry·Lillian OukoVincent W Yang

❮ Previous
Next ❯

Citations

Mar 16, 2007·Digestive Diseases and Sciences·Kimberley S CamacAdrian G Cummins
Jul 19, 2008·Cell Death and Differentiation·Y A Valentin-VegaG Lozano
Dec 31, 2010·Molecular & Cellular Proteomics : MCP·Jenny HanssonMartin Kussmann
Mar 10, 2012·American Journal of Physiology. Cell Physiology·Jinghua LiuLane L Clarke
Sep 13, 2008·Acta Histochemica Et Cytochemica·Tohru MiyataMinoru Haga
Nov 22, 2011·PloS One·Jeffrey J DehmerMichael A Helmrath
Oct 12, 2012·Digestive Diseases and Sciences·Adrian G CumminsPhulwinder K Grover
Feb 26, 2013·Journal of Animal Physiology and Animal Nutrition·B L Bivolarski, E G Vachkova
Aug 18, 2012·Gastrointestinal Endoscopy·Lucinda A HarrisDora Lam-Himlin
Dec 30, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Carmen PinToshiro Sato
Nov 2, 2018·Digestive Diseases and Sciences·Zenab M DudhwalaAdrian G Cummins
Jul 31, 2008·Journal of Pediatric Gastroenterology and Nutrition·Adrian G CumminsFiona M Thompson
Jan 5, 2013·Current Opinion in Gastroenterology·William F Stenson
Jun 27, 2020·BMJ Open Gastroenterology·Zenab Mustansir DudhwalaAdrian Gerard Cummins
Dec 24, 2011·Journal of Pediatric Gastroenterology and Nutrition·Jane K FauserAdrian G Cummins

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.