Postnatal exposure to DINP was associated with greater alterations of lipidomic markers for hepatic steatosis than DEHP in postweaning mice

The Science of the Total Environment
Yan YangYichao Huang

Abstract

The toxicity of the endocrine disruptor di(2-ethylhexyl) phthalate (DEHP) has been extensively studied for its hormonal dysregulation, obesogenic effect and associated metabolic diseases. DEHP's primary substitute di-isononyl phthalate (DINP), however, although increased in annual production globally, requires better understanding of its health effect. Our previous work reported disruptions in plasma lipid profiles, but the metabolic responses following phthalate exposure in the liver, particularly the entire hepatic lipidome, have been lacking. A targeted lipidomic technique was applied to accurately quantify a total of 363 lipid species in the liver of neonatal mice after exposure to a daily dose of 4.8 mg/kg body weight/day from birth throughout lactation. Distinct patterns of disruption for each sum of lipid classes or sub-classes between the genders were the most noticeable. Following DINP administration, female pups were subject to greater changes in phosphatidylethanolamines, bis(monoacylglycero)phosphate and ceramides. In contrast, the males exhibited less changes in the phosphoglycerol backbone-based molecules, whereas glycerol and cholesterol esters were more disrupted by DINP. DEHP, however, induced less changes over...Continue Reading

References

Jun 6, 2000·Nature·S KerstenW Wahli
Jun 14, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher H Hurst, David J Waxman
Dec 5, 2003·Progress in Lipid Research·Rosalind A Coleman, Douglas P Lee
Oct 22, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·J Christopher Corton, Paula J Lapinskas
Jan 14, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yan XuGregory T Knipp
Dec 3, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marjorie A PerazaJeffrey M Peters
Dec 8, 2005·The American Journal of Clinical Nutrition·Carine Klein-PlatatChantal Simon
Feb 9, 2007·Diabetes·Johannes M AertsHermen S Overkleeft
Nov 26, 2008·Journal of Lipid Research·Alfred H MerrillMay Dongmei Wang
Jan 13, 2010·Environmental Health Perspectives·Eiko KoikeHirohisa Takano
Mar 13, 2010·Trends in Endocrinology and Metabolism : TEM·Roger H Unger, Philipp E Scherer
Aug 13, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ainara CanoPatricia Aspichueta
Jul 23, 2013·Journal of Lipid Research·Jacquelyn M WeirPeter J Meikle
Apr 2, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ping MaXu Yang
May 21, 2015·The Journal of Clinical Endocrinology and Metabolism·Teresa M Attina, Leonardo Trasande
Oct 23, 2015·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Yichao HuangRobert Alan Gibson
Jul 30, 2016·Nature Reviews. Endocrinology·Xianlin Han
Oct 21, 2016·Reproductive Toxicology·Jerrold J HeindelFrederick Vom Saal
Nov 4, 2016·Nature Reviews. Endocrinology·Peter J Meikle, Scott A Summers
Mar 17, 2017·Toxicology Letters·Yun-Ho HwangSung-Tae Yee
May 20, 2017·Nature Reviews. Endocrinology·Charles E FouldsCheryl L Walker
Feb 8, 2018·The Journal of Steroid Biochemistry and Molecular Biology·Valentina PomattoPatrizia Bovolin
Oct 12, 2018·Journal of Hazardous Materials·Govindan MalarvannanAdrian Covaci
Sep 11, 2020·Journal of Agricultural and Food Chemistry·Fengjiang SunDaniel Cozzolino

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.