PMID: 9165343May 1, 1997Paper

Postnatal expression of the alpha-thyroid hormone receptor in the rat cochlea

Hearing Research
J Lautermann, W J ten Cate

Abstract

Thyroid hormone receptors belong to the superfamily of nuclear receptors which are expressed in many tissues. Reduced levels of thyroid hormones in acquired or congenital hypothyroidism can lead to hearing loss which may be irreversible. In this study we investigated immunohistochemically the postnatal distribution of the triiodothyronine alpha receptor in the rat cochlea. Cell regions of high sensitivity towards thyroid hormones should have a high density of thyroid hormone receptors. Strong immunoreactivity for the alpha-thyroid hormone receptor was observed in spiral ganglion cells as well as inner and outer hair cells of the cochlea. Staining could be detected during all stages investigated from the first postnatal day up to day 30 and exhibited mainly a nuclear pattern. These observations suggest that spiral ganglion cells and hair cells are target regions of thyroid hormones in the adult and developing cochlea. Thyroid hormones could thus play an important role in the maturation of the inner ear.

Citations

Apr 9, 2002·Journal of Endocrinological Investigation·J Bernal
Feb 13, 2004·Journal of Pediatric Endocrinology & Metabolism : JPEM·Wojciech GawronKrystyna Orendorz-Fraczkowska
Dec 5, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Waldemar NaroznyBoguslaw Mikaszewski
Feb 6, 2020·International Journal of Environmental Research and Public Health·Yao-Te TsaiChih-Wei Luan
May 17, 2006·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Bharti KatbamnaCharles F Ide
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·A Campos-BarrosD Forrest
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Mar 25, 1999·The Laryngoscope·Z Mra, M K Wax
Dec 4, 2003·Thyroid : Official Journal of the American Thyroid Association·Iwan JonesDouglas Forrest
Sep 20, 2015·The European Journal of Neuroscience·Srividya SundaresanMirna Mustapha
Aug 12, 2006·The Annals of Otology, Rhinology, and Laryngology·Waldemar NaroznyBoguslaw Mikaszewski
Nov 19, 2020·International Journal of Environmental Research and Public Health·So Young KimHyo Geun Choi
Aug 28, 2021·Frontiers in Endocrinology·Caio Leônidas Oliveira AndradeHelton Estrela Ramos
Nov 9, 2021·Frontiers in Cellular Neuroscience·Chaorong YuGuoqiang Wan

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