Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a novel model of obesity and puberty

Frontiers of Medicine
Rahim UllahJunfen Fu

Abstract

Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current study, we provided high-fat diet (HFD) to dams during lactation and to pups after weaning. We also developed a novel model of C57BL/6J mouse pups with HFD-induced postnatal obesity. Results showed that feeding with HFD induces fat deposition and obesity in pups. Furthermore, HFD more potently increased the body weight (BW) of male than female pups. HFD-fed female pups were obese, underwent precocious puberty, and showed increased kisspeptin expression in the hypothalamus. However, parental obesity and precocious puberty exerted no synergistic effects on the HFD-induced postnatal weight gain and puberty onset of the pups. Interestingly, some HFD-fed litters with normal BW also exhibited precocious puberty. This finding suggested that diet composition but not BW triggers puberty onset. Our model suggests good construction validity of obesity and precocious puberty. Furthermore, our model can also be used to explore the mutual interactions between diet-induced postnatal childhood obesity and puberty.

References

Jun 1, 1992·The American Journal of Physiology·D B WestR L Atkinson
Jan 1, 1997·Annual Review of Nutrition·M C Neville, M F Picciano
May 20, 2000·Small Ruminant Research : the Journal of the International Goat Association·O MahgoubR J Early1
Oct 30, 2001·The Proceedings of the Nutrition Society·P Trayhurn, J H Beattie
Nov 15, 2001·Obesity Research·P T JamesM Shayeghi
Apr 4, 2003·The Journal of Nutrition·Stephen C WoodsPatrick Tso
Jul 18, 2003·Current Diabetes Reports·Waleed Aldhahi, Osama Hamdy
Aug 21, 2003·Human Reproduction Update·Renato PasqualiAlessandra Gambineri
Aug 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Nicolas de RouxEdwin Milgrom
Jun 1, 1965·Endocrinology·V D RAMIREZ, C H SAWYER
Oct 24, 2003·The New England Journal of Medicine·Stephanie B SeminaraWilliam H Colledge
Dec 12, 2003·The British Journal of Nutrition·Susanna IossaGiovanna Liverini
Feb 19, 2004·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·G Ailhaud, P Guesnet
Jun 29, 2004·Biochemical and Biophysical Research Communications·Hisanori MatsuiTetsuya Ohtaki
Oct 2, 2004·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J S Mayes, G H Watson
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Muhammad ShahabTony M Plant
Mar 31, 2005·Nutrition·Joanne L Slavin
Sep 22, 2005·The Journal of Clinical Endocrinology and Metabolism·Waljit S DhilloStephen R Bloom
Apr 15, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Judith N GorskiBarry E Levin
Aug 3, 2006·Acta Paediatrica·Silvia ScaglioniCarlo Agostoni
Oct 3, 2006·Cell Metabolism·Stephen R Farmer
Dec 15, 2006·Nature·Evan D Rosen, Bruce M Spiegelman
Dec 15, 2006·Nature·Jean-Pierre Després, Isabelle Lemieux
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Xavier d'Anglemont de TassignyWilliam H Colledge
Jul 5, 2008·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Rebecca L Robker
Apr 30, 2010·Laboratory Animals·W L BreslinBrian K McFarlin
Sep 14, 2011·Biochemical and Biophysical Research Communications·Neha GargMartin L Adamo
Jan 13, 2012·The Journal of Clinical Endocrinology and Metabolism·Stephan J Guyenet, Michael W Schwartz
Mar 3, 2012·Clinical and Experimental Reproductive Medicine·Won Heum NahMyung Chan Gye
Mar 16, 2012·Annals of the New York Academy of Sciences·Dongsheng Cai, Tiewen Liu
Jul 17, 2012·Advances in Nutrition·Rebecca Kanter, Benjamin Caballero
Oct 23, 2012·Physiology & Behavior·Elinor L SullivanKatherine A Chamlou
Nov 21, 2012·Nature Reviews. Endocrinology·Vasanti S MalikFrank B Hu

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Citations

Jul 14, 2020·Current Pathobiology Reports·Roberto I MotaEdward M Bahnson
Oct 10, 2020·The Journal of Clinical Endocrinology and Metabolism·Esra KutluYaşar Cesur
Dec 11, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Ting ChenLinqi Chen
Oct 21, 2020·Cell Metabolism·Violeta HerasManuel Tena-Sempere
May 7, 2021·Journal of Cellular and Molecular Medicine·Haiyan PangJianzhong Sheng
Aug 14, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rahim UllahJunfen Fu
Sep 18, 2021·Nutrition & Metabolism·Tingbei BoDehua Wang

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