Postnatal gestational age estimation using newborn screening blood spots: a proposed validation protocol

BMJ Global Health
Malia S Q MurphyKumanan Wilson

Abstract

Knowledge of gestational age (GA) is critical for guiding neonatal care and quantifying regional burdens of preterm birth. In settings where access to ultrasound dating is limited, postnatal estimates are frequently used despite the issues of accuracy associated with postnatal approaches. Newborn metabolic profiles are known to vary by severity of preterm birth. Recent work by our group and others has highlighted the accuracy of postnatal GA estimation algorithms derived from routinely collected newborn screening profiles. This protocol outlines the validation of a GA model originally developed in a North American cohort among international newborn cohorts. Our primary objective is to use blood spot samples collected from infants born in Zambia and Bangladesh to evaluate our algorithm's capacity to correctly classify GA within 1, 2, 3 and 4 weeks. Secondary objectives are to 1) determine the algorithm's accuracy in small-for-gestational-age and large-for-gestational-age infants, 2) determine its ability to correctly discriminate GA of newborns across dichotomous thresholds of preterm birth (≤34 weeks, <37 weeks GA) and 3) compare the relative performance of algorithms derived from newborn screening panels including all availabl...Continue Reading

References

May 1, 1985·British Journal of Obstetrics and Gynaecology·M H HallM L Samphier
Mar 1, 1984·Journal of Epidemiology and Community Health·P BuekensC Robyn
Jan 25, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Isabelle MorinMichael S Kramer
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Jul 4, 2012·Midwifery·Debra Bick
Dec 1, 2012·Patient Education and Counseling·Michael H Farrell, Stephanie A Christopher
Nov 1, 2015·American Journal of Obstetrics and Gynecology·Kumanan WilsonJulian Little
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Dec 13, 2016·EBioMedicine·Kumanan WilsonJulian Little

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