PMID: 9527544Apr 4, 1998Paper

Postnatal localization and morphogenesis of cells expressing the dopaminergic D2 receptor gene in rat brain: expression in non-neuronal cells

The Journal of Comparative Neurology
S HowardA Campagnoni

Abstract

The cellular localization of the dopaminergic D2 receptor (D2R) mRNA and protein was determined during postnatal development, from birth to 35 days, in the rat neostriatum by in situ hybridization histochemistry and immunohistochemistry. To localize and identify more precisely the morphology of cells expressing the D2R mRNA, nonradioactive, digoxigenin in situ hybridization was performed. Throughout this period of development, D2R mRNA and protein were widely expressed by neostriatal cells, adjoining forebrain cells and small cellular processes. Within morphologically identifiable neurons, the expression of the D2 receptor appeared to occur after cell division ceased. D2R gene expression appeared during neuronal migration and followed the developmental pattern of neuronal settling within the neostriatum. Both D2R mRNA and protein appeared to colocalize in neostriatal cells and the labeling of both appeared to accumulate within the cells progressively with age. The structural phenotypes of neostriatal neurons bearing D2R mRNA and protein were diverse throughout postnatal development. The most frequently stained cells were a heterogeneous group of medium spiny and aspiny neurons. Large cells corresponding to aspiny neurons were l...Continue Reading

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Citations

May 20, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dawn N AlbertsonMichael J Bannon
Jul 24, 2010·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Jianqin NiuLan Xiao
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Nov 5, 2020·Molecular Psychiatry·Butian ZhouXiaoping Tong
Sep 30, 2000·Brain Research. Brain Research Reviews·W J Smeets, A González

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