Postnatal maturation of mossy fibre excitatory transmission in mouse CA3 pyramidal cells: a potential role for kainate receptors

The Journal of Physiology
Cécile Marchal, C Mulle

Abstract

Kainate receptors (KARs) are abundantly expressed in the central nervous system at a period of intense synaptogenesis and might participate in the maturation of neural networks. We have described the postnatal development of mossy fibre excitatory synaptic transmission in CA3 pyramidal cells and we have explored the potential role of KARs in synaptic maturation. In CA3 pyramidal cells, mossy fibre stimulation evokes EPSCs as early as postnatal day 3 (P3). At this early stage, mossy fibre (MF)-EPSCs are fully blocked by GYKI 53655, an AMPA receptor (AMPAR) antagonist. A postsynaptic KAR component can only be detected from P6. Thus, AMPAR-EPSCs precede KAR-EPSCs during postnatal maturation at this synapse. All MF-EPSCs display a KAR component after P10. A key issue of the present work is that between P6 and P9, the presence of a postsynaptic KAR component tightly coincides with AMPAR-mediated EPSCs of large amplitude, and with the onset of low frequency facilitation (from 0.1 Hz to 1 Hz), a presynaptic form of short-term synaptic plasticity. In addition, mice lacking functional KARs throughout postnatal development display MF-EPSCs of significantly smaller amplitude at stages of maturation where synaptic KARs are normally present...Continue Reading

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Citations

Jul 19, 2006·Cell and Tissue Research·Paulo Pinheiro, Christophe Mulle
Apr 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Katsunori KobayashiHidenori Suzuki
Mar 18, 2011·Molecular Brain·Katsunori KobayashiHidenori Suzuki
Jan 11, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Scott A WilkeAnirvan Ghosh
Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Man TangRoderick R McInnes
Jul 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Paulo S PinheiroChristophe Mulle
Feb 17, 2009·Neurochemical Research·Zheng WuLiecheng Wang
Oct 17, 2006·The European Journal of Neuroscience·Katsunori KobayashiHidenori Suzuki
Jan 5, 2013·The EMBO Journal·Mario CartaChristophe Mulle
Aug 24, 2010·The European Journal of Neuroscience·Benjamin R RostDietmar Schmitz
Apr 18, 2014·The European Journal of Neuroscience·Mario CartaChristophe Mulle
May 21, 2016·The European Journal of Neuroscience·Jimmy GeorgeThierry Amédée
Feb 10, 2017·Neurology. Genetics·Yomayra F GuzmánGeoffrey T Swanson
May 29, 2018·Psychiatry and Clinical Neurosciences·Juzoh UmemoriEero Castrén
Dec 5, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C Beas-ZárateD Ortuño-Sahagún
Mar 9, 2018·Frontiers in Molecular Neuroscience·Shivakumar SubbannaBalapal S Basavarajappa
Oct 3, 2020·Frontiers in Cellular Neuroscience·Sebnem KesafClaudio Rivera
Oct 21, 2006·Biochemical Society Transactions·J R Mellor
Dec 9, 2017·The Journal of Physiology·Mario CartaChristophe Mulle
Nov 16, 2018·Nature Communications·Gaël BarthetChristophe Mulle
Apr 29, 2021·Neuropharmacology·Sari E LauriTomi Taira
Jul 12, 2021·Neuropharmacology·Christophe Mulle, Valérie Crépel
Aug 11, 2021·American Journal of Human Genetics·Jacob R StolzGeoffrey T Swanson

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