PMID: 1673153Feb 1, 1991

Postnatal maturation of the GABAergic system in rat neocortex

Journal of Neurophysiology
H J Luhmann, D A Prince


1. The postnatal maturation of intracortical inhibitory circuitry and the development of responses to applied gamma-aminobutyric acid (GABA) and baclofen were studied in pyramidal and nonpyramidal neurons from layers II and III of the rat primary somatosensory and primary visual cortex, in vitro. 2. Depolarizing spontaneous inhibitory postsynaptic potentials (IPSPs) could be recorded in approximately 70% of the young (postnatal day 4-10; P4-10), juvenile (P11-16), and adult cells (P28-41), respectively, when they were loaded with nitrate. At all ages these spontaneous events could be blocked by application of the GABAA receptor antagonist bicuculline methiodide (BMI), indicating that they were mediated by activation of GABAA receptors. 3. In 122 of the 130 adult cells tested, standardized electrical stimulation of the white matter or layer VI evoked a brief excitatory postsynaptic potential (EPSP), followed by both a fast (f-) and a long-latency (l-)IPSP. Similar stimuli evoked a biphasic IPSP in only 51 of the 98 juvenile and in only 1 of the 56 young neurons studied. The mean peak conductance of the f-IPSP and the l-IPSP increased significantly from 50.2 and 7.5 nS, respectively, in juvenile cells to 84.2 and 18.0 nS, respect...Continue Reading


Feb 1, 1995·The European Journal of Neuroscience·H J LuhmannU Heinemann
Jan 22, 1994·The Journal of Comparative Neurology·E M KasperC Blakemore
Jan 1, 1997·The European Journal of Neuroscience·R Schröder, H J Luhmann
Jul 19, 2000·Journal of Neurophysiology·R S DammermanA R Kriegstein
Oct 13, 2000·The European Journal of Neuroscience·S X SimonianAllan E Herbison
Dec 4, 2001·Journal of Neurophysiology·M MartinaD Paré
Nov 13, 2001·The European Journal of Neuroscience·M Boller, M Schmidt
Sep 5, 2002·Nature Reviews. Neuroscience·Yehezkel Ben-Ari
Feb 25, 2005·Brain : a Journal of Neurology·Anne WilliamsonHoby Hetherington
Nov 10, 2006·Journal of Neurophysiology·Marat MinlebaevRustem Khazipov
May 24, 2008·Journal of Neurophysiology·Sylvain RheimsYuri Zilberter
Jan 13, 2011·The Journal of Physiology·Rudolf A DeiszRobert Nitsch
Nov 12, 2010·Journal of Neurophysiology·Giao B Hang, Yang Dan
Jun 15, 2011·Neuroreport·Olga MyakharSergei Kirischuk
Dec 12, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jill M ZemianekThomas B Shea
Nov 26, 2014·Developmental Neurobiology·Yi-Chun Hsieh, Adam C Puche
Oct 28, 2014·Frontiers in Neuroengineering·Takashi Tateno, Jun Nishikawa
Oct 7, 2015·Frontiers in Cellular Neuroscience·Miho Watanabe, Atsuo Fukuda
Aug 6, 2017·Scientific Reports·Shun Qiang LoGeorge J Augustine
Sep 8, 2017·Frontiers in Cellular Neuroscience·Marilena Griguoli, Enrico Cherubini
Oct 6, 2017·Frontiers in Cellular Neuroscience·Matthew T ColonneseYasunobu Murata
Apr 4, 2019·The European Journal of Neuroscience·Alexander van der BourgH J Luhmann
Dec 1, 1994·The Journal of Comparative Neurology·J PaysanJ M Fritschy
Jul 1, 1996·The Journal of Experimental Zoology·C InagakiX T Zeng

Related Concepts

Chloride Ion Level
Resting Potentials
August Rats
Antagonist Muscle Action
Multiform Layer of Cerebral Cortex
Biologic Development

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.