Postnatal Ontogeny of the Cranial Base and Craniofacial Skeleton in Male C57BL/6J Mice: A Reference Standard for Quantitative Analysis

Frontiers in Physiology
Siddharth R VoraTimothy C Cox

Abstract

Growth of the craniofacial skeleton is a complex process controlled by both genetic and epigenetic factors, perturbations of which can lead to varying degrees of dysmorphology. Mouse models that recapitulate clinical craniofacial phenotypes are instrumental in studying the morphogenetic progression of diseases as well as uncovering their genetic and molecular bases. Commonly encountered phenotypes in these models include defects in the cranial base synchondroses, calvarial sutures, mandible or the midface, or any combination thereof, with the concurrent presence of altered overall craniofacial growth. However, the literature lacks an adequate normative timeline of developmental events and growth trends that shape the mouse craniofacial skeleton. In this report, we analyzed the postnatal craniofacial ontogeny (from postnatal day 7 [P7] through to P112) of male mice from the most widely used inbred mouse strain, C57BL/6J, using high-resolution microcomputed tomography (μCT) in combination with classic morphometric approaches. We also evaluated cranial base synchondroses at the histological level, and compared it to μCT-generated data to assess the timing and pattern of closure of these structures. Our data underscore the complex ...Continue Reading

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Jun 28, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rachel A MenegazJason M Organ
Sep 30, 2017·Frontiers in Physiology·Xiaoxi WeiFei Liu
Nov 10, 2018·Frontiers in Physiology·Anshul K KulkarniHonghao Zhang
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Jul 13, 2021·Frontiers in Cell and Developmental Biology·Pranidhi BaddamDaniel Graf

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Methods Mentioned

BETA
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Drishti
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