PMID: 9432070Jan 31, 1998Paper

Postnatal persistence of epidermoid rests in the human middle ear

The Laryngoscope
J L LevineW L Meyerhoff

Abstract

It is widely believed that congenital cholesteatoma originates from epidermoid cell rests in the temporal bone. Congenital cholesteatomas of the anterior-superior middle ear may arise from such a rest, known as the epidermoid formation (EF), which has been described by Michaels and others. The EF is thought to disappear by 33 weeks' gestation in most cases; however, if it persists beyond fetal life, it may provide a nidus for cholesteatoma formation. The authors studied human temporal bones from individuals ranging from 20 weeks' gestation to 5 years of age to investigate pre- and postnatal occurrence of the EF. A total of 106 temporal bones were surveyed; 76 of these were fetal specimens and 30 were postnatal. EFs were present in 14 (18.4%) of the fetal specimens; they were identified in four (13.3%) of the postnatal temporal bones, with the oldest being 2 years, 7 months of age. Multiple EFs within a single temporal bone were also present in some cases. Although the EFs were composed of cells morphologically identical to those of the external ear canal epidermis, none of the specimens showed keratinization. These findings support the contention that EFs do occasionally persist into postnatal life and may be a source of choles...Continue Reading

References

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Citations

May 12, 2000·The Laryngoscope·K L Horn
May 4, 2000·Topics in Magnetic Resonance Imaging : TMRI·M J Pisaneschi, B Langer
Sep 29, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Robert J CaugheyBradley W Kesser
Jun 5, 2003·The Laryngoscope·Jianning LiangAnthony Wright
Jul 9, 2004·American Journal of Otolaryngology·Darryl T MuellerGlenn Isaacson
Aug 29, 2006·American Journal of Otolaryngology·Hiromi KojimaHiroshi Moriyama
Jun 6, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Yuka MoritaSugata Takahashi
Dec 3, 2014·International Journal of Pediatric Otorhinolaryngology·Andrea BacciuVincenzo Vincenti
Sep 28, 2017·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Yuka MoritaArata Horii
Nov 4, 1998·Clinical Otolaryngology and Allied Sciences·T S LeeA Wright
Aug 19, 2007·The Journal of Laryngology and Otology·R PersaudA K Bhattacharyya
Apr 25, 2015·Vestnik otorinolaringologii·N A Mileshina, E V Kurbatova
Sep 15, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Léa DistinguinFrançoise Denoyelle
Nov 26, 2020·Ear, Nose, & Throat Journal·Bridget MacDonaldDaniela Carvalho
Sep 19, 2020·The Journal of Craniofacial Surgery·Zhengcai Lou

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