Postnatal remodeling of dendritic structure and spine density in gonadotropin-releasing hormone neurons

Endocrinology
Elizabeth C CottrellAllan E Herbison

Abstract

The GnRH neurons represent the output cells of the neuronal network controlling gonadal function. Their activation initiates the onset of puberty, but the underlying mechanisms remain unclear. Using a GnRH-green fluorescent protein mouse model, we have been able to fill individual GnRH neurons with biocytin in the acute brain slice preparation to examine their morphological characteristics across puberty. GnRH neurons in prepubertal male mice [postnatal d 10-15 (PND10-15)] exhibited half as many dendritic and somal spines as adult male mice (>PND60; P < 0.05) but, surprisingly, a much more complex dendritic tree with 5-fold greater branch points (P < 0.05). Experiments examining somal and proximal dendritic spine numbers in vivo, in perfusion-fixed tissue from GnRH-green fluorescent protein mice, revealed the same pattern of approximately twice as many spines on adult GnRH neurons compared with PND10 male mice (P < 0.01). In contrast to the spine density alterations, reflecting changing excitatory input, confocal immunofluorescence studies revealed no differences in the numbers of vesicular gamma-aminobutyric acid transporter-immunoreactive elements adjacent to GnRH soma or proximal dendrites in prepubertal and adult male mice....Continue Reading

References

Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·K KusanoS Wray
Dec 1, 1994·Plant Physiology·V MettP H Reynolds
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·D MitsushimaE Terasawa
Jul 1, 1993·Frontiers in Neuroendocrinology·G E HoffmanJ G Verbalis
Jun 1, 1996·Journal of Neurophysiology·G M Shepherd
Dec 31, 1997·Nature·S L McIntireE M Jorgensen
Nov 19, 1997·Trends in Neurosciences·Y Ben-AriJ L Gaiarsa
Oct 3, 2000·Frontiers in Neuroendocrinology·L M Flanagan-Cato
Oct 13, 2000·The European Journal of Neuroscience·J A SimA E Herbison
Feb 13, 2001·Endocrine Reviews·E Terasawa, D L Fernandez
May 18, 2001·Trends in Neurosciences·Y Ben-Ari
Jun 28, 2002·Brain Research. Brain Research Reviews·John C FialaKristen M Harris
Jul 20, 2002·Frontiers in Neuroendocrinology·S Wray
Oct 3, 2002·Nature Reviews. Neuroscience·Rachel O L Wong, Anirvan Ghosh
Nov 29, 2002·Molecular Endocrinology·R Anthony DeFazioSuzanne M Moenter
Feb 20, 2003·Trends in Neurosciences·Stephen R Williams, Greg J Stuart
Sep 17, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Erich N OttemSandra L Petersen
Jan 22, 2005·Development·Elizabeth C MarinLiqun Luo
Feb 8, 2005·Trends in Cell Biology·Bing Ye, Yuh Nung Jan
Mar 5, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Li-Jen LeeReha S Erzurumlu
Mar 17, 2005·Endocrinology·Stephanie B Seminara, Ursula B Kaiser
May 11, 2005·Journal of Neurobiology·Bradley M Cooke, Catherine S Woolley
Aug 27, 2005·Endocrinology·Suzanne M Moenter, R Anthony DeFazio
Dec 13, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Seong-Kyu HanAllan E Herbison
Jun 20, 2006·Molecular and Cellular Endocrinology·Jenny Clarkson, Allan E Herbison

❮ Previous
Next ❯

Citations

Jun 15, 2011·Journal of Computational Neuroscience·Dávid CsercsikZsolt Liposits
Mar 6, 2007·Reviews in Endocrine & Metabolic Disorders·J T Smith, I J Clarke
Jun 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Rebecca E CampbellAllan E Herbison
Nov 1, 2008·Integrative and Comparative Biology·Carson B Roberts, Kelly J Suter
Oct 11, 2012·American Journal of Physiology. Endocrinology and Metabolism·Johanna R RochesterPei-San Tsai
Jul 16, 2010·The Journal of Clinical Investigation·Sara A DivallAndrew Wolfe
Jun 30, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter J HemondKelly J Suter
May 6, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paolo Emanuele ForniSusan Wray
Mar 28, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Luis Miguel Garcia-SeguraLydia L DonCarlos
Jan 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Aleisha M MooreRebecca E Campbell
Mar 19, 2013·Frontiers in Neuroendocrinology·Jenny Clarkson
Jun 16, 2010·Frontiers in Neuroendocrinology·Vincent PrevotMarc Baroncini
Dec 23, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Laverne Camille Melón, Jamie Maguire
Dec 22, 2007·Experimental Neurology·Murat YildirimAndrea C Gore
Sep 18, 2007·Frontiers in Neuroendocrinology·Juan RoaManuel Tena-Sempere
Dec 17, 2014·Bulletin of Mathematical Biology·Xingjiang Chen, James Sneyd
Feb 5, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christine L JasoniAllan E Herbison
Sep 30, 2010·Journal of Neuroendocrinology·B M Cooke
Dec 15, 2010·The European Journal of Neuroscience·Sergio R OjedaUrsula Sandau
Sep 3, 2010·Brain Research·Karl J IremongerAllan E Herbison
Jul 10, 2013·Molecular and Cellular Endocrinology·Sean A McFaddenDenise D Belsham
Oct 13, 2010·Molecular and Cellular Endocrinology·Virginie MansuyFrançois P Pralong
Mar 23, 2013·Channels·Rachael NorbergKelly J Suter
Jan 9, 2007·Trends in Endocrinology and Metabolism : TEM·Tony M Plant
May 3, 2016·Nature Neuroscience·Andrea MessinaVincent Prevot
Sep 5, 2014·PLoS Computational Biology·Thomas H HrahaRichard K P Benninger
May 21, 2016·Nature Reviews. Endocrinology·Allan E Herbison

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.