Postnatal renal adaptation in preterm and term lambs

Reproduction, Fertility, and Development
L M BerryM G Ervin

Abstract

The present experiments determined if increases in renal reabsorptive capacity during the transition from fetal to neonatal life are gestation dependent. Renal function was studied in chronically-catheterized fetal lambs (133 +/- 1 days; term, 145-150 days). Additionally, renal function was studied in anaesthetized, ventilated, caesarean-delivered preterm lambs (109-139 days gestation) and term lambs (148 days gestation), and in 2-day-old spontaneously-delivered term lambs. Newborns < or = 120 days old received surfactant to facilitate ventilation and maintenance of physiologic blood gases. Two hours after caesarian delivery, urine osmolality, urine flow, glomerular filtration rate (GFR), and fractional sodium excretion (FENa) values were similar for all gestations. Relative to fetal values, caesarean-delivered newborn renal values included lower urine flow rates (0.20 +/- 0.03 v. 0.05 +/- 0.01 mL min-1 kg-1), higher urine osmolalities (118 +/- 15 v. 422 +/- 16 mOsmol kg-1 H2O), and no differences in GFR or FENa. Relative to caesarean-delivered newborns, 2-day newborn renal function included higher values for GFR (0.7 +/- 0.1 v. 3.0 +/- 0.1 mL min-1 kg-1) and urine osmolality (724 +/- 32 mosmol kg-1 H2O), and lower FENa (7.0 +/...Continue Reading

Citations

Dec 1, 1996·Acta Paediatrica·J N van den Anker
Feb 1, 1996·The Journal of Pediatrics·J F PadburyD H Polk
Apr 20, 2016·BMC Physiology·Angela E Vinturache, Francine G Smith
Sep 5, 1998·The American Journal of Physiology·N WadaM Ikegami
Apr 2, 2011·American Journal of Physiology. Renal Physiology·Russell D BrownKaren J Gibson

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