Postnatal stem/progenitor cells derived from the dental pulp of adult chimpanzee.

BMC Cell Biology
Pei-Hsun ChengAnthony W S Chan

Abstract

Chimpanzee dental pulp stem/stromal cells (ChDPSCs) are very similar to human bone marrow derived mesenchymal stem/stromal cells (hBMSCs) as demonstrated by the expression pattern of cell surface markers and their multipotent differentiation capability. ChDPSCs were isolated from an incisor and a canine of a forty-seven year old female chimpanzee. A homogenous population of ChDPSCs was established in early culture at a high proliferation rate and verified by the expression pattern of thirteen cell surface markers. The ChDPSCs are multipotent and were capable of differentiating into osteogenic, adipogenic and chondrogenic lineages under appropriate in vitro culture conditions. ChDPSCs also express stem cell (Sox-2, Nanog, Rex-1, Oct-4) and osteogenic (Osteonectin, osteocalcin, osteopontin) markers, which is comparable to reported results of rhesus monkey BMSCs (rBMSCs), hBMSCs and hDPSCs. Although ChDPSCs vigorously proliferated during the initial phase and gradually decreased in subsequent passages, the telomere length indicated that telomerase activity was not significantly reduced. These results demonstrate that ChDPSCs can be efficiently isolated from post-mortem teeth of adult chimpanzees and are multipotent. Due to the alm...Continue Reading

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R C AllsoppC B Harley
Jan 1, 1990·Folia primatologica; international journal of primatology·K G Gould, L G Young
May 1, 1997·Journal of Virology·F J NovembreH M McClure
Jan 13, 1998·Nature Genetics·U M MartensP M Lansdorp
Aug 19, 2000·Journal of Medical Primatology·K G Gould, J Johnson-Ward
Aug 25, 2000·Genome Research·A Varki
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·S GronthosS Shi
Aug 25, 2001·Trends in Cognitive Sciences·J Call
Oct 24, 2001·Trends in Genetics : TIG·J G Hacia
Jan 10, 2002·Immunological Reviews·E A Muchmore
Apr 13, 2002·Tissue & Cell·E B Smithwick, L G Young
Apr 16, 2002·Science·Wolfgang EnardSvante Pääbo
Jul 12, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Derek E Wildman
Jul 31, 2002·Journal of Dental Research·S GronthosS Shi
Jan 28, 2003·Trends in Genetics : TIG·Jianying Gu, Xun Gu
Mar 11, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Markéta MarvanováGarry Wong
Aug 26, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jody Hey
Sep 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Darwin J ProckopJeffery L Spees
Oct 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mario CáceresCarrolee Barlow
Jan 31, 2004·Lab Animal·Linda Brent
Jun 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jens Bukh
Oct 12, 2004·Gene·Max HolzerMichel Goedert
Nov 4, 2004·Journal of the National Cancer Institute·Matus StudenyMichael Andreeff
Apr 19, 2005·Cancer Research·Akira NakamizoFrederick F Lang
May 10, 2005·Brain Research. Brain Research Protocols·Lingling LuHui Yang
Jul 12, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gregorio LainoGianpaolo Papaccio
Sep 2, 2005·Nature·Frans B M de Waal
Sep 3, 2005·Stem Cells and Development·Reza IzadpanahBruce A Bunnell
Sep 28, 2005·Journal of Endodontics·Misako Nakashima, Akifumi Akamine
Oct 14, 2005·Journal of Cellular Physiology·Gregorio LainoGianpaolo Papaccio
Nov 10, 2005·Annals of Medicine·H Kalervo Väänänen
Dec 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·James R MunozDarwin J Prockop
Feb 8, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·M MakuwaP Roques
Mar 3, 2006·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·William D Hopkins
Jun 2, 2006·Neuroreport·Jared P TaglialatelaWilliam D Hopkins

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Citations

Oct 8, 2013·Archives of Oral Biology·Golnaz MoradArash Khojasteh
Mar 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Simi M ChackoPeriannan Kuppusamy
Sep 14, 2011·BMC Cell Biology·Brooke R SnyderAnthony W S Chan
Nov 20, 2012·Indian Journal of Human Genetics·Sumit Narang, Nidhi Sehgal
Jun 6, 2013·Cell and Tissue Research·Juliana Malta da CunhaMarcelo Cavenaghi Pereira da Silva
Jul 19, 2011·Journal of Endodontics·Waruna Lakmal DissanayakaLijian Jin
Jan 10, 2012·International Journal of Paediatric Dentistry·Ying WangGuoqiang Guan
Sep 18, 2012·Archives of Oral Biology·Nobuyuki Kawashima
Apr 30, 2016·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Fatemeh SholehvarAkbar Vahdati
Oct 28, 2019·Current Stem Cell Research & Therapy·Chih-Sheng KoWen-Ta Su
Jun 2, 2018·Stem Cells International·Lihua LuoQingsong Ye
Aug 30, 2020·International Journal of Molecular Sciences·Anna Labedz-MaslowskaEwa Zuba-Surma
Apr 3, 2012·Journal of Cell Science·Maher AtariLuis Giner

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Methods Mentioned

BETA
Assay
ELISA
X-ray
FACS
flow cytometry

Software Mentioned

Flowjo

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