Postnatal weight loss in substitute methadone-exposed infants: implications for the management of breast feeding

Archives of Disease in Childhood. Fetal and Neonatal Edition
C DrydenHelen Mactier

Abstract

It is widely accepted that maternal drug-exposed infants demonstrate excessive early weight loss, but this has not previously been quantified. Among 354 term, substitute methadone-exposed infants, median maximal weight losses were 10.2% and 8.5% for breast- and formula-fed infants, respectively (p=0.003). Weight loss was less in small for gestational age compared to appropriately grown infants (p<0.001). There was no association between maximal weight loss and plasma sodium concentration (p=0.807). Relative to non-drug exposed infants, weight loss was more marked in formula-fed infants, 48% of whom demonstrated weight loss in excess of the 95th centile (compared to 23% of exclusively breastfed infants; p<0.001). Median weight loss nadir was on day 5, excepting those infants exclusively breastfed (day 4). These data suggest that excessive neonatal weight loss among breastfed infants of drug-misusing mothers does not necessarily reflect poorly established lactation and may help to guide management of breast feeding in this population.

Citations

Oct 12, 2013·Early Human Development·Helen Mactier
Aug 27, 2013·Clinics in Perinatology·Kendra GrimRobert T Wilder
May 11, 2017·Pharmacotherapy·Amy P HolmesEliana N Kurzum
Jul 19, 2016·Substance Abuse : Research and Treatment·Lisa E GravesSucheta Sinha
Jul 26, 2014·The Journal of Perinatal & Neonatal Nursing·Denise Maguire
Nov 7, 2019·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Nicole YonkeLudmila N Bakhireva
Aug 29, 2020·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Kailey Taylor, Denise Maguire
Dec 22, 2020·The Cochrane Database of Systematic Reviews·Adrienne PahlRoger Soll
Mar 3, 2021·Journal of Developmental Origins of Health and Disease·Tammy E CorrIan M Paul
Aug 13, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Michael T FavaraZubair H Aghai
Jul 1, 2020·American Journal of Perinatology·Amy L LembeckDavid A Paul

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