Postoperative 5-fluorouracil versus intraoperative mitomycin C in high-risk glaucoma filtering surgery: extended follow up

Clinical & Experimental Ophthalmology
Cengiz AkarsuBerati Hasanreisoglu

Abstract

To compare the long-term efficacy and safety of postoperative subconjunctival 5-fluorouracil (5-FU) injections with that of intraoperative mitomycin C (MMC) in eyes at high risk for failure of trabeculectomy. In a retrospective, non-randomized comparative trial, 36 eyes of 36 consecutive patients at high risk for failure of trabeculectomy underwent glaucoma filtering surgery with either postoperative subconjunctival 5-FU injections (19 eyes) or intraoperative application of MMC (17 eyes). Intraocular pressure, number of postoperative antiglaucoma medications, postoperative visual acuity, interventions, and complications were evaluated. Overall success (intraocular pressure </=21 mmHg) at 1 year was 73.6% in the 5-FU group and 82.3% in the MMC group. The cumulative 4-year success was 52.6% in the 5-FU group and 60.5% in the MMC group (P = 0.6). At 4-year follow up, mean +/- SD intraocular pressures were 17.58 +/- 4.01 mmHg in the 5-FU group and 13.33 +/- 3.36 mmHg in the MMC group (P = 0.01). There was no significant difference in the number of post-operative medications (P = 0.84), appearance of blebs (P = 0.20), final visual acuity (P = 1.00), and complications (P > 0.05) between the groups. These results suggest that both pos...Continue Reading

References

Jan 1, 1992·Ophthalmology·J Whiteside-MichelR Ritch
Dec 1, 1991·Archives of Ophthalmology·Y KitazawaM Minobe
Mar 1, 1991·Ophthalmology·S S Palmer
Jan 1, 1990·Journal of Ocular Pharmacology·C W ChenC C Lee
Feb 15, 1990·American Journal of Ophthalmology·H D JampelH A Quigley
Nov 1, 1987·Survey of Ophthalmology·G L Skuta, R K Parrish
Sep 1, 1987·Ophthalmology·E J RockwoodW Feuer
Oct 1, 1984·Ophthalmology·M G GresselR K Parrish
Apr 1, 1984·Ophthalmology·D K HeuerD R Anderson
May 1, 1983·Archives of Ophthalmology·E M AddicksA L Robin
Jan 1, 1995·Ophthalmology·K A Lamping, J K Belkin
Sep 15, 1993·American Journal of Ophthalmology·P T ZachariaJ S Schuman
Apr 1, 1996·Ophthalmology·E J HigginbothamG L Skuta
Aug 1, 1996·Archives of Ophthalmology·D S GreenfieldH W Flynn
Jul 1, 1997·Ophthalmology·T C ChenM A Viana
Mar 8, 1996·Current Opinion in Ophthalmology·P T Khaw, C S Migdal
Mar 8, 1996·Current Opinion in Ophthalmology·H Mietz
Oct 12, 2000·Eye·M F CordeiroP T Khaw

❮ Previous
Next ❯

Citations

May 28, 2011·Japanese Journal of Ophthalmology·Melis PalamarEmil Yusifov
Apr 24, 2008·International Ophthalmology·Emily C Greenlee, Young H Kwon
Jun 20, 2008·International Ophthalmology·Saleh A Al ObeidanAhmed M Abu El-Asrar
Dec 1, 2012·Journal of Ocular Biology, Diseases, and Informatics·Shashi Kumar BhaskerKamlesh Singh
Feb 20, 1999·Survey of Ophthalmology·W L Haynes, W L Alward
Aug 31, 2000·Ophthalmology·L D HarrisA Z Chuang
Nov 16, 2001·Journal of Cataract and Refractive Surgery·T ShaarawyA Mermoud
Mar 22, 2002·Progress in Retinal and Eye Research·M Francesca Cordeiro
Oct 28, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Zhong-Jie LinXiao-He Lu
Apr 30, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Wool Suh, Changwon Kee
Feb 8, 2007·Drugs·Lekha M AbrahamIgal Leibovitch
Jun 7, 2013·Middle East African Journal of Ophthalmology·Girum W Gessesse, Karim F Damji
Jan 15, 2014·Ocular Immunology and Inflammation·Saleh A Al ObeidanAhmed M Abu El-Asrar
Dec 22, 2006·Expert Opinion on Drug Safety·Ali A Mearza, Ioannis M Aslanides
May 10, 2007·Acta Ophthalmologica Scandinavica·Dario SistoCarlo Sborgia
Aug 15, 2008·Clinical & Experimental Ophthalmology·Merih OnolBerati Hasanreisoğlu
Apr 22, 2006·Clinical & Experimental Ophthalmology·M Hannah Pu de GuzmanAdrian C Farinelli
Nov 1, 2006·Clinical & Experimental Ophthalmology·Guy J Ben Simon, Yoseph Glovinsky
Aug 11, 2015·Biochemical and Biophysical Research Communications·Ling-Feng DongQin Jiang
Apr 17, 2004·International Ophthalmology Clinics·Sean-Paul A AtreidesAdam C Reynolds
Oct 4, 2005·International Ophthalmology Clinics·Douglas A Kohl, David S Walton
Jun 17, 2015·Ophthalmic Plastic and Reconstructive Surgery·Hatem A TawfikWesam M Osman
Jul 28, 2020·Indian Journal of Ophthalmology·Vijayalakshmi A Senthilkumar, Chitaranjan Mishra
Jul 25, 2007·Journal français d'ophtalmologie·A LabbéC Baudouin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
L A Al-AswadP A Netland
International Ophthalmology Clinics
A P Da Mata, C S Foster
© 2022 Meta ULC. All rights reserved