Postoperative adjuvant chemotherapy inhibits early recurrence of early gastric carcinoma

Cancer Chemotherapy and Pharmacology
T OkamuraK Sugimachi

Abstract

Data on 300 patients with early gastric carcinoma who underwent curative resection were analyzed for the suppressive effects of postoperative adjuvant chemotherapy on early recurrences. Retrospective grouping was done as follows: no chemotherapy (NC) group (169 patients), mitomycin C (MMC) group (108), and another group (23). In all, 24 patients (16 in the NC, 6 in the MMC, and 2 in the other group) who died of other diseases within 5 years after surgery were excluded. Therefore, data on 153 individuals in the NC and 102 in the MMC group were analyzed. The recurrence rate in patients with Pen A type carcinoma, with a propensity toward an early recurrence in the liver, was 37.5% in the NC and 9.1% in the MMC group. Among 27 Pen A type patients, 3- and 4-year survival was significantly higher in those receiving MMC (100%) than in those given NC (62.5%). Recurrences in the liver occurred in 6/14 of the NC patients within 3 years after surgery, whereas there were no recurrences in 11 MMC patients. Thus, the postoperative adjuvant chemotherapy with mitomycin-C has an inhibitory effect on early recurrence in patients with Pen A type early gastric carcinoma.

References

Aug 1, 1986·Annals of Surgery·W L BringazeI Cohn
Oct 1, 1986·The British Journal of Surgery·J M OleagoitiaJ Hernandez-Calvo
Mar 1, 1987·Archives of Surgery·W E LongoI M Modlin
Jun 1, 1984·World Journal of Surgery·S AbeS Suehiro
May 1, 1984·Annals of Surgery·K J CarterW P Ritchie
Jan 1, 1981·World Journal of Surgery·H H GentschJ Giedl
Jul 1, 1980·Cancer·T MatsusakaK Inokuchi

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Citations

Jun 4, 1998·Journal of Surgical Oncology·M MoritaK Sugimachi
Jul 17, 1998·The British Journal of Surgery·N KuriharaM Kitajima
Jul 1, 1992·Medical Hypotheses·R Schrek
Dec 1, 1990·The British Journal of Surgery·K HiokiM Yamamoto
Jul 1, 1995·The British Journal of Surgery·S FolliA Vio
Jan 1, 1993·Journal of Surgical Oncology. Supplement·G LuporiniG Pancera

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