Postoperative analgesia with continuous epidural sufentanil and bupivacaine: a prospective study in 614 patients

Anesthesia and Analgesia
A A BroekemaP J Hennis

Abstract

To assess the efficacy and safety of postoperative analgesia with continuous epidural sufentanil and bupivacaine, we performed a prospective study in 614 patients undergoing major surgery. Before surgical incision, all patients received an initial dose of 50 micrograms sufentanil in 6-10 mL bupivacaine 0.125% via a lumbar or thoracic catheter. After 1 h, a continuous infusion was started with 50 micrograms sufentanil in 50 mL bupivacaine 0.125% at a rate of 6-10 mL/h. The infusion was continued postoperatively for 1-5 days or longer, depending on the type of operation and the patient's analgesic need. In the majority of patients, adequate pain relief was obtained at rest and during movement. Late respiratory depression was observed in three patients; in most patients only minor side effects were seen. Technical complications during epidural puncture or insertion of the catheter were 4% and 3%, respectively. We conclude that continuous epidural sufentanil and bupivacaine is safe and effective.

References

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Citations

Apr 20, 2002·Lancet·John R A RiggUNKNOWN MASTER Anaethesia Trial Study Group
Mar 31, 2009·Annales Françaises D'anesthèsie Et De Rèanimation·D Fletcher, C Jayr
Dec 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H Wulf
Mar 7, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Thomas StandlJochen Schulte Am Esch
Jun 14, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·V CompèreB Dureuil
Nov 26, 2010·Irish Journal of Medical Science·T TanC Power
Mar 15, 2005·Anesthesiology Clinics of North America·Jeffrey M Richman, Christopher L Wu

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