Postoperative Analgesia with Intravenous Paracetamol and Dexmedetomidine in Laparoscopic Cholecystectomy Surgeries: A Prospective Randomized Comparative Study

International Journal of Applied & Basic Medical Research
Ridhima SharmaSukhminder Jit Singh Bajwa

Abstract

Therapeutic use of nonopioid analgesic such as paracetamol (PCM) is an alternative to opioids, so to avoid the established side effects associated with opioids, PCM is commonly used due to its analgesic and antipyretic effects. Recently, dexmedetomidine has also emerged on the anesthesia front with a potential role of providing postoperative analgesia. The present study was conducted to compare and assess the quality and duration of analgesia with PCM and dexmedetomidine using visual analog scale (VAS). One hundred patients between the age of 18 and 60 years of the American Society of Anesthesiologists grade I and II undergoing laparoscopic cholecystectomy surgery were randomly allocated into two groups (n = 50). Each patient received either 1 g intravenous PCM, in 100 ml solution before incision (Group I), or i.v. dexmedetomidine 1 μg/kg as bolus over 10 min followed by infusion of 0.5 μg/kg/h (Group II). Postoperatively, the following parameters were observed: quality and duration of analgesia, hemodynamic parameters, time to the first dose of rescue analgesia, sedation, and any postoperative complication or side effects. Statistical analysis was carried out using an unpaired t-test for quantitative parameters and nonparametr...Continue Reading

References

Sep 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·N V ChandrasekharanDaniel L Simmons
Jan 22, 2008·European Journal of Anaesthesiology·E G ElvanU Aypar
May 24, 2008·Anesthesia and Analgesia·Burcu TufanogullariDavid A Provost
Dec 1, 2012·Korean journal of anesthesiology·Jung-Kyu ParkHyun-Tae Kim

❮ Previous
Next ❯

Methods Mentioned

BETA
Sedation
hysterectomy

Software Mentioned

SPSS

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.