Postoperative chemoradiotherapy for high-risk head-and-neck squamous cell carcinoma

International Journal of Radiation Oncology, Biology, Physics
Sandro V PorcedduL J Peters

Abstract

To describe the use of postoperative concurrent chemoradiotherapy, with either weekly cisplatin or carboplatin, for high-risk head-and-neck squamous cell carcinoma (HNSCC) in a single institutional setting. Between July 1999 and January 2003, 47 patients were treated with postoperative chemoradiotherapy. Of the 47 patients, 41 (87%) had Stage III-IV disease. The predominant primary site was the oral cavity in 24 patients (51%), 27 had nodal disease with extracapsular extension, and 26 had positive or close mucosal margins (<5 mm). Ten patients had undergone resection of recurrent disease after previous surgery. Twenty-seven (57%) were treated with cisplatin, and the remaining patients received carboplatin because of contraindications to cisplatin. The median radiotherapy dose was 60 Gy (range, 50-66 Gy). Of the 47 patients, 45 (96%) completed at least four of the six planned doses of chemotherapy and 45 (96%) completed the planned course of radiotherapy. Nineteen patients (40%) had confluent mucositis, eight (17%) had Grade 3-4 hematologic toxicity, and four (9%) had febrile neutropenia. No treatment-related deaths occurred. The estimated 2-year locoregional control, progression-free survival, and overall survival rate was 73%,...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Jun 1, 1996·Australian and New Zealand Journal of Medicine·M J MillwardR Hicks
Dec 1, 1996·International Journal of Radiation Oncology, Biology, Physics·J M BachaudN Daly-Schveitzer
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T G WendtA Schalhorn
Mar 4, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J CorryL J Peters
Oct 13, 2001·International Journal of Radiation Oncology, Biology, Physics·K K AngL J Peters

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Citations

Oct 21, 2006·Radiation Oncology·Gabriela StuderChristoph Glanzmann
Feb 24, 2009·Clinical Oncology : a Journal of the Royal College of Radiologists·R D FarhadiehR Smee
Jul 11, 2006·Critical Reviews in Oncology/hematology·J A de Hullu, A G J van der Zee
Nov 21, 2014·Japanese Journal of Clinical Oncology·Naomi KiyotaMasato Fujii
Sep 20, 2016·Expert Opinion on Pharmacotherapy·Stefan Hartmann, Jennifer R Grandis
Mar 15, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandro Virgilio PorcedduDanny Rischin
Feb 3, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alesha A Thai, Danny Rischin
Apr 20, 2011·Journal of Medical Imaging and Radiation Oncology·June CorryLester J Peters
Aug 15, 2008·Annals of the Royal College of Surgeons of England·Sanjeev MisraN C Misra

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