Postoperative Clostridium difficile infection with PCR ribotype 078 strain identified at necropsy in five Thoroughbred racehorses

The Veterinary Record
H NiwaK Nakai

Abstract

Clostridium difficile is an important cause of acute enterocolitis in horses. We describe five cases of C difficile infection occurring postoperatively in Thoroughbred racehorses. Following diarrhoea or colic accompanied by a marked increase in packed cell volume (to ≥60 per cent) and leucopenia (≤4000 cells/μl) within two to four days after surgery in all five horses, four of them died or were euthanased because of colitis or severe diarrhoea. In these four horses, necrotising entero-typhlo-colitis was revealed by postmortem examination, and C difficile was recovered from the contents of the small and/or large intestine. The remaining horse was euthanased because of marked decline in general condition and the presence of a lung abscess, from which C difficile was isolated. The horse had had severe postoperative diarrhoea before the onset of respiratory disorder; laboratory tests for C difficile were not performed on the faeces. All C difficile isolates were toxin-A-positive, toxin-B-positive and actin-specific ADP-ribosyltransferase (CDT)-positive. The isolates were indistinguishable by pulsed field gel electrophoresis analysis, PCR ribotyping, and slpA sequence typing, and the slpA sequences and PCR ribotype patterns were ide...Continue Reading

References

Jul 1, 1995·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·B R MadewellJ Silva
Jul 17, 1998·Journal of Clinical Microbiology·H KatoE B Wasito
Jul 24, 2003·Equine Veterinary Journal·V BåverudA Gunnarsson
Apr 16, 2005·Clinical Microbiology Reviews·Daniel E Voth, Jimmy D Ballard
Nov 23, 2006·Veterinary Microbiology·Luis G ArroyoJ Scott Weese
Apr 13, 2007·Journal of Clinical Microbiology·Kevin KeelJ Glenn Songer
Jul 25, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E SawabeN Okamura
Mar 11, 2008·Journal of Clinical Microbiology·Abraham GoorhuisEdward J Kuijper
Sep 24, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Abraham GoorhuisEd J Kuijper
May 2, 2009·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·J Glenn SongerRobert D Glock
Dec 17, 2009·Comparative Immunology, Microbiology and Infectious Diseases·Maria Cristina OssiprandiLaura Zerbini
Mar 26, 2011·Journal of Medical Microbiology·Sara TheanThomas V Riley
May 17, 2011·Veterinary Microbiology·Carlos E Medina-TorresHenry R Staempfli
Mar 13, 2012·Hospital Practice·Billie Bartel, Elizabeth Gau
Jul 13, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M H WilcoxM W D Wren

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Citations

Aug 21, 2014·Archives of Virology·Manabu NemotoTakashi Kondo
Jan 7, 2020·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·J Scott Weese
Feb 6, 2018·Annals of Laboratory Medicine·Nobuaki Mori, Takashi Takahashi
Jan 2, 2019·Tropical Medicine and Infectious Disease·Deirdre A Collins, Thomas V Riley
Jul 10, 2019·Frontiers in Public Health·Daniel R Knight, Thomas V Riley
Sep 6, 2021·Equine Veterinary Journal·Marco A F LopesGal Kelmer

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