Postoperative cognitive dysfunction and mortality following lung transplantation

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Patrick J SmithScott M Palmer

Abstract

Preliminary evidence suggests that postoperative cognitive dysfunction (POCD) is common after lung transplantation. The impact of POCD on clinical outcomes has yet to be studied. The association between POCD and longer-term survival was therefore examined in a pilot study of posttransplantation survivors. Forty-nine participants from a prior randomized clinical trial underwent a neurocognitive assessment battery pretransplantation and 6 months posttransplantation, including assessments of the domains of Executive Function (Trail Making Test, Stroop, Digit Span), Processing Speed (Ruff 2 and 7 Test, Digit Symbol Substitution Test), and Verbal Memory (Verbal Paired Associates, Logical Memory, Animal Naming, and Controlled Oral Word Association Test). During a 13-year follow-up, 33 (67%) participants died. Greater neurocognition was associated with longer survival (hazard ratio [HR] = 0.49 [0.25-0.96], P = .039), and this association was strongest on tests assessing Processing Speed (HR = 0.58 [0.36-0.95], P = .03) and Executive Function (HR = 0.52 [0.28-0.97], P = .040). In addition, unadjusted analyses suggested an association between greater Memory performance and lower risk of CLAD (HR = 0.54 [0.29-1.00], P = .050). Declines i...Continue Reading

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Citations

Apr 10, 2019·Journal of Palliative Medicine·Eric P NolleyMatthew R Morrell
Nov 7, 2019·Current Opinion in Organ Transplantation·Patrick J Smith, Linda C Cendales
May 9, 2019·Seminars in Cardiothoracic and Vascular Anesthesia·Justin N TawilMichael L Boisen
Dec 10, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Joanna M SchaenmanSangeeta Bhorade
May 20, 2021·Journal of Clinical Psychology in Medical Settings·Roland TomasiVera von Dossow
Jun 21, 2019·Current Opinion in Organ Transplantation·Joanna SchaenmanMaricar Malinis
Dec 16, 2021·Anesthesiology·Matteo Di NardoLorenzo Del Sorbo

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