Postoperative complications with neuromuscular blocking drugs and/or reversal agents in obstructive sleep apnea patients: a systematic review

BMC Anesthesiology
Khawaja Rashid HafeezJean Wong

Abstract

Neuromuscular blocking drugs (NMBD) are administered intra-operatively to facilitate intubation and to achieve muscle relaxation for surgical procedures. Incomplete reversal of NMBD can lead to adverse events in the postoperative period. Patients with obstructive sleep apnea (OSA) may be at higher risk of complications related to the use of NMBD. The objectives of this systematic review were to determine whether: 1) OSA patients are at higher risk of postoperative complications from the use of NMBD than non-OSA patients, and 2) the choice of NMBD reversal agent affects the risk of postoperative complications in OSA patients. A literature search of multiple databases was conducted up to April 2017. The inclusion criteria were: (1) adult surgical patients (≥18 years old) with OSA diagnosed by polysomnography, or history, or suspected by screening questionnaire; (2) patients who were given NMBD and/or NMBD reversal agents intraoperatively; (3) reports on postoperative adverse events, particularly respiratory events were available; (4) published studies were in English; and (5) RCTs or observational cohort studies. The quality of evidence was determined by the Oxford Center for Evidence Based Medicine levels of evidence. Out of 412...Continue Reading

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Citations

Sep 11, 2018·Current Opinion in Anaesthesiology·Mahesh NagappaFrances Chung
Aug 8, 2019·Current Opinion in Anaesthesiology·Crispiana CozowiczStavros G Memtsoudis
Jun 3, 2020·Journal of Intensive Care·J Ross RenewRichard C Prielipp
Apr 16, 2021·Anesthesia and Analgesia·Crispiana Cozowicz, Stavros G Memtsoudis
Apr 16, 2021·Anesthesia and Analgesia·Thomas J AltreeDanny J Eckert
Jun 6, 2021·Irish Journal of Medical Science·Vesna MarjanovicChristian Breschan

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