Postoperative cytological findings from the use of the Integran microfibrillar collagen hemostatic matrix in conization

Diagnostic Cytopathology
Shinji ToyodaEiwa Ishida

Abstract

The Integran microfibrillar collagen hemostatic matrix is one form of microfibrillar collagen hemostat. This form has a sheet-type structure and has explicitly been used in Japan. In gynecology, this sheet-type matrix has helped effect uterine surface hemostasis, especially in myomectomy and cervical conization. However, cytotechnologists and pathologists have overlooked the foreign materials used for conization in postoperative cervical cytology. We report two cases describing the characteristic cervical cytology findings when Integran was used in conization. The first case was a 67-year-old woman who underwent conization because of cervical intraepithelial neoplasia (CIN) 3. Thirty-six days after the surgery, many cylindrical fragments of glossy acellular materials appeared in the cervical cytology. Fortunately, the content did not impede the diagnosis of NILM. The patient then underwent hysterectomy two months after conization. Surgical specimen revealed a high degree of inflammation and granulation without malignancy. Following surgery, the cylindrical fragments disappeared from microscopic findings. The second case was a 45-year-old woman who underwent conization because of CIN3. Thirty-four days after the surgery, many tu...Continue Reading

References

Jul 2, 2003·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Hideaki MiyamotoEnjo Hata
Feb 3, 2009·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Bayar HexigToshie Tsuchiya
Jul 14, 2012·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Koichi Fujiu, Hideaki Miyamoto
Jun 29, 2014·Journal of Minimally Invasive Gynecology·Rafał WatrowskiJochen Möckel
Dec 30, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Antonio D'AndrilliErino A Rendina

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Citations

Oct 8, 2019·Cancer Cytopathology·Silvia Hernández-BonillaBlanca Vicandi
Apr 18, 2018·Diagnostic Cytopathology·Rafael Martínez-Girón, Cristina Martínez-Torre

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