Postoperative follow-up strategy based on recurrence dynamics for non-small-cell lung cancer

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Katsuya WatanabeMunetaka Masuda

Abstract

Our study was designed to visually represent recurrence patterns after surgery for non-small-cell lung cancer (NSCLC) with the use of event dynamics and to clarify postoperative follow-up methods based on the times of recurrence. A total of 829 patients with NSCLC who underwent complete pulmonary resection from 2005 to 2007 in 9 hospitals affiliated with the Yokohama Consortium of Thoracic Surgeons were studied. Event dynamics, based on the hazard rate, were evaluated. Only first events involving the development of distant metastases, local recurrence or both were considered. The effects of sex, histological type, pathological stage and age were studied. The hazard rate curve displayed an initial surge that peaked about 6-8 months after surgery. The next distinct peak was noted at the end of the second year of follow-up. On non-parametric kernel smoothing, the maximum peak was found 6-8 months after surgery in men. In women, the highest peak occurred 22-24 months after surgery, which was about 16 months later than the peak in men. The peak timing of the hazard curve was not affected by histological type, pathological stage or age in either sex. Our results suggest that the timing of recurrence after surgery for lung cancer is c...Continue Reading

References

Oct 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R J Simes, M Zelen
Dec 1, 1995·Annals of Surgery·K S VirgoF E Johnson
Jun 23, 1999·Chest·R N YounesD Deheinzelin
Nov 18, 2000·The Annals of Thoracic Surgery·V WesteelA Depierre
Dec 24, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David G PfisterUNKNOWN American Society of Clinical Oncology
Sep 7, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Maria Q BaggstromMark A Socinski
Oct 6, 2007·Chest·K Robert ShenUNKNOWN American College of Chest Physicians
Nov 27, 2007·Nature Clinical Practice. Oncology·Romano DemicheliMichael Baum
Jul 15, 2009·Advances in Cancer Research·Benjamin D Hedley, Ann F Chambers
Nov 11, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jessamy A BoydChris R Kelsey
Mar 20, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Romano DemicheliChris R Kelsey
Apr 7, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Mia Schmidt-HansenElise Hasler
Mar 19, 2013·Clinical Lung Cancer·Chris R KelseyRomano Demicheli
Jul 19, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J VansteenkisteUNKNOWN ESMO Guidelines Working Group
Apr 25, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M MalvezziE Negri
Oct 31, 2014·General Thoracic and Cardiovascular Surgery·Munetaka MasudaHiroyasu Yokomise

❮ Previous
Next ❯

Citations

Oct 18, 2018·CA: a Cancer Journal for Clinicians·David A MahviChandrajit P Raut
May 10, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Katsuya WatanabeMunetaka Masuda
Aug 12, 2020·International Journal of Radiation Biology·Xin-Bin PanXiao-Dong Zhu
Aug 6, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Mireia DiazUNKNOWN Lung Cancer Prevention LUCAPREV research group
Oct 7, 2021·Journal of Chest Surgery·Dae Hyeon KimSamina Park

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Hiroyuki AdachiMunetaka Masuda
Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Romano DemicheliChris R Kelsey
Current Oncology Reports
Giorgio V Scagliotti, Silvia Novello
Zhonghua zhong liu za zhi [Chinese journal of oncology]
Yu-Shun GaoRu-Gang Zhang
European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Yoshiki KozuTakashi Nakajima
© 2022 Meta ULC. All rights reserved