Postoperative fulminant varicella zoster virus hepatitis with fatal outcome: a case report

Zeitschrift für Gastroenterologie
U DrebberH P Dienes

Abstract

Fulminant hepatitis due to varicella zoster virus (VZV) infection has a poor prognosis although an effective treatment is available. We present a case of fulminant hepatic failure (FHF) as a result of disseminated VZV infection in a long-term alcoholic patient who underwent laryngectomy and radical neck dissection due to squamous cell carcinoma of the larynx. Post-mortem examination revealed the diagnosis of fulminant hepatitis and infection with VZV. Viral inclusion bodies were found in the hypopharyngeal mucosa as well as in the liver tissue. In these tissues VZV was detected by PCR. The clinical presentation is suggestive for a reactivation of VZV without cutaneous signs of herpes zoster during a state of immunosuppression. Differential diagnosis comprises hepatitis by other Herpes group viruses and toxic hepatic injury.

Citations

Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marlén Alvite-CanosaMaría Generosa Crespo-Leiro
May 16, 2014·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ritesh Kumar AgrawalaAnoj Kumar Baliarsinha
Oct 27, 2018·Case Reports in Hepatology·Elizabeth Caitlin Brewer, Leigh Hunter
Sep 5, 2021·BMJ Case Reports·Christopher FangWei Wen Ang

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