Postoperative hypofractionated stereotactic brain radiation (HSRT) for resected brain metastases: improved local control with higher BED10

Journal of Neuro-oncology
Aryavarta M S KumarMitchell Machtay

Abstract

HSRT directed to large surgical beds in patients with resected brain metastases improves local control while sparing patients the toxicity associated with whole brain radiation. We review our institutional series to determine factors predictive of local failure. In a total of 39 consecutive patients with brain metastases treated from August 2011 to August 2016, 43 surgical beds were treated with HSRT in three or five fractions. All treatments were completed on a robotic radiosurgery platform using the 6D Skull tracking system. Volumetric MRIs from before and after surgery were used for radiation planning. A 2-mm PTV margin was used around the contoured surgical bed and resection margins; these were reviewed by the radiation oncologist and neurosurgeon. Lower total doses were prescribed based on proximity to critical structures or if prior radiation treatments were given. Local control in this study is defined as no volumetric MRI evidence of recurrence of tumor within the high dose radiation volume. Statistics were calculated using JMP Pro v13. Of the 43 surgical beds analyzed, 23 were from NSCLC, 5 were from breast, 4 from melanoma, 5 from esophagus, and 1 each from SCLC, sarcoma, colon, renal, rectal, and unknown primary. Ten...Continue Reading

References

Apr 12, 2003·Technology in Cancer Research & Treatment·Roy A Patchell, William F Regine
Oct 18, 2005·International Journal of Radiation Oncology, Biology, Physics·Timothy KorytkoDouglas B Einstein
Dec 13, 2005·International Journal of Radiation Oncology, Biology, Physics·Ajay K BhatnagarL Dade Lunsford
Jan 24, 2007·International Journal of Radiation Oncology, Biology, Physics·Lourdes M GarciaGijsbert P Raaphorst
Mar 25, 2009·International Journal of Radiation Oncology, Biology, Physics·Jack F Fowler
Sep 29, 2009·International Journal of Radiation Oncology, Biology, Physics·Brian J BlonigenJohn C Breneman
Oct 25, 2012·International Journal of Radiation Oncology, Biology, Physics·Tomohiko MatsuyamaNatsuo Oya
Feb 4, 2014·Journal of Neuro-oncology·Giuseppe MinnitiLucio Trodella
Apr 24, 2014·American Journal of Clinical Oncology·Kamran A AhmedNikhil G Rao
Jul 26, 2014·Journal of Neuro-oncology·Selvan RajakesariBrian M Alexander
Oct 29, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vinai GondiMinesh P Mehta
Nov 6, 2015·Journal of Korean Neurosurgical Society·Won Joo JeongYoung Hyun Cho
May 14, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Takeaki IshiharaRyohei Sasaki
Dec 14, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·M DoréF Thillays
Oct 5, 2017·International Journal of Radiation Oncology, Biology, Physics·Audrey KellerDelphine Antoni

❮ Previous
Next ❯

Citations

Jul 18, 2019·Journal of Neuro-oncology·Jeffrey I TraylorGanesh Rao
Apr 19, 2020·Journal of Neuro-oncology·Achiraya TeyateetiBruce E Pollock
Oct 14, 2019·Journal of Neuro-oncology·Hima B MusunuruAndrew M Baschnagel
Feb 13, 2021·Practical Radiation Oncology·Diana A Roth O'BrienTheodore H Schwartz
Apr 17, 2021·Radiation Oncology·Giuseppe MinnitiClaus Belka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.