Postoperative infections following total knee replacement: an epidemiological study

Journal of Chemotherapy
L LazzariniF de Lalla

Abstract

From January 1991 to June 1997 217 patients undergoing monolateral or bilateral total knee replacement (TKR) were consecutively enrolled in a prospective study on the incidence of postoperative infections and related risk factors. Regional antimicrobial prophylaxis (teicoplanin 400 mg) was used in 263 (95%) prostheses implanted; in the remaining 14 implants (5%) perioperative antibiotic prophylaxis (teicoplanin 800 mg) was administered as usual by systemic route. None of the patients experienced local or systemic adverse effects. Over the 2-year follow-up period, 8 (2.9%) primary site infectious complications were recorded, i.e. 4 superficial infections, which were cured without involvement of the prostheses, and 4 deep infections, which required prosthesis removal. Six infections occurred in patients who had undergone previous surgery of the same knee joint, and 2 in patients undergoing primary TKR (p= 0.0005); diabetic patients had infections (13%) more frequently than non-diabetic patients (1.9%, p=0.01). Staphylococci were the leading organisms isolated from infections; however 3 strains of Escherichia coli were isolated from patients who had undergone a previous prosthesis implantation at the same knee joint. Regional admi...Continue Reading

References

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Citations

Dec 21, 2013·The Journal of Arthroplasty·Erik HansenKoji Yamada
Jan 23, 2016·The Journal of Arthroplasty·Olubusola BrimmoCarlos A Higuera
May 25, 2010·European Journal of Internal Medicine·Esa JämsenTeemu Moilanen
Nov 22, 2005·Infectious Disease Clinics of North America·Camelia E Marculescu, Douglas R Osmon
Jan 28, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Erik HansenKoji Yamada
Jul 10, 2004·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Brian MinnemaAndrew E Simor
May 22, 2003·Dermatologic Clinics·Melissa Dawn Babcock, Roy C Grekin
Dec 14, 2011·The Journal of Bone and Joint Surgery. American Volume·John P MeehanRichard H White

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