Postoperative Inflammatory Response in Crohn's Patients: A Comparative Study

Journal of Crohn's & Colitis
A de Buck van OverstraetenA D'Hoore

Abstract

Surgery for Crohn's disease [CD] can be complicated by an enhanced inflammatory response. This retrospective study aims to compare the inflammatory response measured by C-reactive protein [CRP] in patients operated for CD with patients undergoing similar surgery for colorectal cancer [CRC]. All CD patients undergoing an ileocaecal resection between February 2001 and December 2013 were retrieved from a prospectively maintained database. The same number of patients with a CRC of the ascending colon, undergoing a laparoscopic right hemicolectomy between March 2009 and June 2014, were retrieved from a CRC database. CRP level during the first 7 postoperative days was used as primary outcome. Totals of 112 consecutive CD patients (male 40.2%; median age: 32.3 yrs; interquartile range [IQR]: 25.2-45.1) and 112 consecutive CRC patients [male 53.6%; median age 71.6 yrs; IQR: 64.7-77.5] were included. Postoperative CRP level in the CD group was on average 27% higher compared with the CRC group [p = 0.02]. The day-specific differences in CRP values were 21% (p = 0.021, 95% confidence interval [CI]: 3% 41%), 41% [p = 0.005, 95% CI: 11%-79%], 49% [p = 0.007, 95% CI: 11%-96%], and 49% [p = 0.006, 95% CI: 12%-100%] higher for CD patients at D...Continue Reading

References

Apr 12, 2000·The British Journal of Surgery·N P WoodcockJ MacFie
Dec 11, 2002·Diseases of the Colon and Rectum·Yoshio TakesueTaijiro Sueda
Mar 1, 2006·Lancet·Daniel J B MarksAnthony W Segal
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Dec 25, 2013·PloS One·Rajesh SomasundaramGwenny M Fuhler
Jun 28, 2014·Digestive Diseases·Yvette MergaJonathan M Rhodes

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Citations

Mar 5, 2016·Gut Microbes·Bota CuiFaming Zhang
Sep 16, 2019·Digestive Diseases and Sciences·Janice JangShannon Chang
May 15, 2020·Updates in Surgery·Michele CarvelloAntonino Spinelli
Jun 19, 2021·International Journal of Colorectal Disease·Ioannis PoziosClaudia Seifarth

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