Abstract
The aim of this study was to retrospectively analyze the effect of postoperative intensity-modulated radiotherapy (IMRT) on recurrence and survival in lymph node-positive or stage III thoracic esophageal squamous cell carcinoma (TESCC) patients, and evaluate its role in TESCC therapy. We enrolled 538 patients who underwent radical resection with (S + R) or without (S) postoperative IMRT. The median total postoperative IMRT dose was 60 Gy. The Kaplan-Meier method, log-rank test, and chi-square test were used for survival rate calculation, univariate analysis, and sites of failure analysis, respectively. The 5-year overall survival (OS) and disease-free survival rates were 32.7 and 27.3%, respectively. The 5-year OS rates of lymph node-positive S and S + R patients were 28.4 and 38.8%, respectively (p < 0.001). The 5-year OS rates of stage III S and S + R patients were 24.0 and 38.0%, respectively (p = 0.001). Postoperative IMRT resulted in significantly decreased intrathoracic and supraclavicular recurrence, and obviously delayed median local recurrence and systemic metastases. Systemic metastases increased following postoperative IMRT. Postoperative IMRT reduces local recurrence and improves survival in lymph node-positive or s...Continue Reading
Citations
Nov 5, 2015·The Annals of Thoracic Surgery·San-Gang WuQun Li
Sep 19, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yijun LuoMinghuan Li
Apr 16, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jinsong YangYexiong Li
Dec 19, 2018·Cancer Medicine·Jing YuConghua Xie
Mar 12, 2019·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·X-W CaiX-L Fu
Nov 22, 2018·Medicine·Xiao-Han ZhaoShu-Chai Zhu
Jan 8, 2020·World Journal of Gastrointestinal Oncology·Ya ZengXu-Wei Cai
Apr 21, 2020·Journal of Oncology·Xing-Hua BaiGuang Li
Sep 16, 2020·BMC Cancer·Xiao ChangZefen Xiao
May 19, 2019·Thoracic Cancer·Wenjie NiDekang Fang
Feb 20, 2020·BMC Cancer·Wenjie NiDali Wang
Jun 17, 2020·Medicine·Shuai QieChan Liu
Nov 9, 2018·World Journal of Surgical Oncology·Yichun WangFan Wang
Oct 18, 2020·Annals of the New York Academy of Sciences·Xue-Feng LengYou-Sheng Mao
May 11, 2021·Annals of Surgical Oncology·Xiao ChangZefen Xiao
Jul 23, 2021·Future Oncology·Xiang GuXiaojun Chen
Jul 27, 2021·The Oncologist·Wenjie NiYushun Gao