Postoperative intensity-modulated radiotherapy improved survival in lymph node-positive or stage III thoracic esophageal squamous cell carcinoma

Oncology Research and Treatment
Wencheng ZhangJie He

Abstract

The aim of this study was to retrospectively analyze the effect of postoperative intensity-modulated radiotherapy (IMRT) on recurrence and survival in lymph node-positive or stage III thoracic esophageal squamous cell carcinoma (TESCC) patients, and evaluate its role in TESCC therapy. We enrolled 538 patients who underwent radical resection with (S + R) or without (S) postoperative IMRT. The median total postoperative IMRT dose was 60 Gy. The Kaplan-Meier method, log-rank test, and chi-square test were used for survival rate calculation, univariate analysis, and sites of failure analysis, respectively. The 5-year overall survival (OS) and disease-free survival rates were 32.7 and 27.3%, respectively. The 5-year OS rates of lymph node-positive S and S + R patients were 28.4 and 38.8%, respectively (p < 0.001). The 5-year OS rates of stage III S and S + R patients were 24.0 and 38.0%, respectively (p = 0.001). Postoperative IMRT resulted in significantly decreased intrathoracic and supraclavicular recurrence, and obviously delayed median local recurrence and systemic metastases. Systemic metastases increased following postoperative IMRT. Postoperative IMRT reduces local recurrence and improves survival in lymph node-positive or s...Continue Reading

Citations

Sep 19, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yijun LuoMinghuan Li
Apr 16, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jinsong YangYexiong Li
Mar 12, 2019·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·X-W CaiX-L Fu
Jan 8, 2020·World Journal of Gastrointestinal Oncology·Ya ZengXu-Wei Cai
Jun 17, 2020·Medicine·Shuai QieChan Liu
Oct 18, 2020·Annals of the New York Academy of Sciences·Xue-Feng LengYou-Sheng Mao

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