Postoperative Outcomes for Patients with Non-B Non-C Hepatocellular Carcinoma: A Subgroup Analysis of Patients with a History of Hepatitis B Infection

Annals of Surgical Oncology
Kiyohiko OmichiNorihiro Kokudo

Abstract

Hepatocellular carcinoma (HCC) not associated with active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, termed non-B non-C HCC (nBnC-HCC), is reportedly correlated with better survival outcomes than HBV- or HCV-related HCC. However, the nBnC-HCC population includes patients with a history of HBV infection possessing anti-hepatitis B core antibodies (HBcAb), and the oncologic significance of this finding remains unclear. A retrospective review of the data for 562 patients who underwent curative resection for primary HCC was performed. The clinical outcomes were compared among the following four groups: HBV group (HBsAg-positive), HCV group (HCVAb-positive), HBcAb-positive nBnC-HCC group, and pure nBnC-HCC group (negative for these viral markers). The HBcAb-positive nBnC-HCC group showed better overall survival (OS) and recurrence-free survival (RFS) rates than the HBV, HCV, and pure nBnC-HCC groups (5-year OS 89.4 vs 68.4, 62.0, and 66.2 %; P = 0.003; 5-year RFS 53.8 vs 31.4, 28.1, and 33.6 %; P = 0.01). A multivariate analysis confirmed that a history of HBV is associated with a lower risk of OS (hazard ratio [HR] 0.23; 95 % confidence interval [CI] 0.09-0.56; P = 0.001) and RFS (HR 0.45; 95 % CI 0.27-0.73; P = ...Continue Reading

References

Jan 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E E PowellL W Powell
Jul 1, 1993·Seminars in Surgical Oncology·M MakuuchiS Kawasaki
Jul 1, 1999·The New England Journal of Medicine·I CacciolaG Raimondo
Dec 16, 2000·Digestive Diseases and Sciences·S Z ParkA J Czaja
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H KuperO Nyrén
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Akitaka ShibuyaToshio Morizane
Nov 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jorge A MarreroAnna S Lok
Mar 26, 2004·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yoshiyuki YamagishiHiromasa Ishii
Jun 11, 2005·Journal of Gastroenterology and Hepatology·Hironori TanakaYasushi Shiratori
Jun 1, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Winnie YeoPaul K S Chan
Dec 12, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Junichi ShindohNorihiro Kokudo
May 16, 2013·Annals of Surgery·Tohru UtsunomiyaUNKNOWN Liver Cancer Study Group of Japan
Jan 11, 2014·World Journal of Gastroenterology : WJG·Arvind ReddyMilton Mutchnick
Feb 14, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Carlo SaittaTeresa Pollicino

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Citations

Feb 23, 2019·Annals of Surgical Oncology·Derek J Erstad, Kenneth K Tanabe
Jun 7, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Shan-Shan WuWei Wang
Jul 16, 2017·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shinji ItohYoshihiko Maehara

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