Postoperative prophylactic antibiotics for facial fractures: A systematic review and meta-analysis

The Laryngoscope
Andy M HabibJacob P Ossoff

Abstract

Perioperative antibiotic prophylaxis in patients undergoing surgery for maxillofacial fractures is standard practice. However, the use of postoperative antibiotic prophylaxis remains controversial. This systematic review and meta-analysis sought to evaluate the effect of postoperative antibiotic therapy on the incidence of surgical site infection (SSI) in patients with maxillofacial fractures. MEDLINE, Embase, and the Cochrane Library were searched from inception through October 2017. Randomized controlled trials (RCTs) and cohort studies evaluating the efficacy of pre-, peri-, and postoperative antibiotic prophylaxis in preventing SSI in maxillofacial fractures were included. Data were extracted from studies using a standardized data collection form, with two reviewers independently performing extraction and quality assessment for each study. Risk ratios (RRs) for SSI were pooled using a random-effects model. Among 2,150 potentially eligible citations, 13 studies met inclusion criteria and provided data to be included in a meta-analysis. The addition of postoperative antibiotic prophylaxis to a standard preoperative and/or perioperative antibiotic regimen showed no significant difference in the risk of SSI (RR = 1.11 [95% CI: ...Continue Reading

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Citations

Dec 12, 2020·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Miles J PfaffJustine C Lee
Feb 4, 2021·Journal of Periodontology·Alexandra M McKennaDavid B Banach
Apr 14, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Elizabeth H WickGregory H Branham
May 22, 2021·The British Journal of Oral & Maxillofacial Surgery·T MilicD Gebauer
Nov 5, 2021·Archives of Craniofacial Surgery·Yeo Reum JeonSeum Chung

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