PMID: 2503148Jun 17, 1989Paper

Postoperative radiotherapy and late mortality: evidence from the Cancer Research Campaign trial for early breast cancer

BMJ : British Medical Journal
J L HaybittleM Baum

Abstract

To identify any excess mortality caused by adjuvant radiotherapy for early breast cancer. Prospective randomised clinical trial. Two thousand subjects needed for study to have a 90% chance of detecting a difference in survival rate of 7% with 95% significance. Patients were followed up until June 1988, giving follow up of 158-216 months. A multicentre trial mainly drawing patients from centres in the United Kingdom. 2800 Women presenting with clinical stage I or II carcinoma of the breast from June 1970 to April 1975. One group of women (n = 1376) had simple mastectomy followed by immediate postoperative radiotherapy (1320 to 1510 rets). The remaining women (n = 1424) had simple mastectomy with subsequent careful observation of the axilla, radiotherapy being delayed until there was obvious progression or recurrence of disease locally. Increased mortality in patients treated with radiotherapy from causes other than breast cancer. Survival was measured from time of first treatment to death or last follow up. Deaths from any cause and from specified causes were counted as events. Comparison over the whole follow up showed a slight excess mortality in the group treated with radiotherapy (relative risk 1.04; 95% confidence interval ...Continue Reading

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