Postoperative radiotherapy for elderly patients with stage III lung cancer.

Cancer
Juan P WisniveskyEmilia Bagiella

Abstract

The potential role of postoperative radiation therapy (PORT) for patients who have completely resected, stage III nonsmall cell lung cancer (NSCLC) with N2 disease remains controversial. By using population-based data, the authors of this report compared the survival of a concurrent cohort of elderly patients who had N2 disease treated with and without PORT. By using the Surveillance, Epidemiology, and End Results (SEER) registry linked to Medicare records, 1307 patients were identified who had stage III NSCLC with N2 lymph node involvement diagnosed between 1992 and 2005. Propensity scoring methods and instrumental variable analysis were used to compare the survival of patients who did and did not receive PORT after controlling for selection bias. Overall, 710 patients (54%) received PORT. Propensity score analysis indicated that PORT was not associated with improved survival in patients with N2 disease (hazard ratio [HR], 1.11; 95% confidence interval [CI], 0.97-1.27). Analyses that were limited to patients who did or did not receive chemotherapy, who received intermediate-complexity or high-complexity radiotherapy planning, or adjusted for time trends produced similar results. The instrumental variable estimator for the abso...Continue Reading

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Nov 7, 2009·American Journal of Respiratory and Critical Care Medicine·Juan P WisniveskyEmilia Bagiella

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Citations

Mar 29, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Suchit H PatelBhupesh Parashar
Mar 19, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A G PallisM O'Brien
Oct 17, 2015·Expert Review of Anticancer Therapy·Paola Claudia SaccoCesare Gridelli
Nov 11, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·John L MikellKristin A Higgins
Jul 3, 2013·Critical Reviews in Oncology/hematology·Jordi RemonMontserrat Zanui
Aug 21, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Masato InazuTsuyoshi Yamanaka
Mar 11, 2015·International Journal of Radiation Oncology, Biology, Physics·John M VarlottoChristopher R Kelsey
Jul 26, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R BlancoI Nuñez
Jul 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A G PallisM O'Brien

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