Postoperative radiotherapy for lung cancer: improvement in locoregional control using three-dimensional compared with two-dimensional technique

International Journal of Radiation Oncology, Biology, Physics
Laurence Masson-CôtéAnne Dagnault

Abstract

To determine whether lung cancer patients treated with three-dimensional (3D) postoperative radiotherapy (PORT) have more favorable outcomes than those treated with two-dimensional (2D) PORT. We retrospectively analyzed the charts of 153 lung cancer patients who underwent PORT with curative intent at our center between 1995 and 2007. The patients were grouped according to the RT technique; 66 patients were in the 2D group and 87 in the 3D group. The outcomes included locoregional control, survival, and secondary effects. All patients were treated using a linear accelerator at a total dose of approximately 50 Gy and 2 Gy/fraction. A few patients (21%) also received chemotherapy. Most tumors were in the advanced stage, either Stage II (30%) or Stage III (65%). The main clinical indications for PORT were positive resection margins (23%) and Stage pN2 (52%) and pN1 (22%). The patient characteristics were comparable in both groups. Kaplan-Meier analysis showed that the 3D technique significantly improved the locoregional control rate at 5 years compared with the 2D technique (81% vs. 56%, p = .007 [Cox]). The 2D technique was associated with a more than twofold increased risk of locoregional recurrence (hazard ratio, 2.7; 95% confid...Continue Reading

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Citations

Mar 29, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Suchit H PatelBhupesh Parashar
Jun 25, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Lucyna KępkaAnna Zawadzka
Jun 17, 2016·Cancer Biotherapy & Radiopharmaceuticals·Guo-Ping ShanYi-Wei Yang
Jun 27, 2015·PloS One·Seung Jun LeeJong Deog Lee
Jun 25, 2015·Revista da Associação Médica Brasileira·E WeltmanUNKNOWN Brazilian Society for Radiation Oncology

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