Postoperative serum CA19-9, CEA and CA125 predicts the response to adjuvant chemoradiotherapy following radical resection in pancreatic adenocarcinoma

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Huaxiang XuLiang Liu

Abstract

To evaluate the prediction of benefits from adjuvant chemoradiotherapy by postoperative serum CA19-9, CA125 and CEA. The relations between benefits from adjuvant chemoradiotherapy and levels of postoperative serum CA19-9, CA125 and CEA were investigated in 804 pancreatic adenocarcinoma patients who received radical resection. Adjuvant chemoradiotherapy was an independent factor for late recurrence [12.2 vs. 8.5 months, P = 0.001 for recurrence free survival (RFS)] and long survival [23.7 vs. 17.0 months, P < 0.001 for overall survival (OS)] in resected pancreatic adenocarcinoma. Postoperative serum CA19-9, CA125 and CEA were independent risk predictors for poor surgical outcome in pancreatic adenocarcinoma (P < 0.001 for all). Adjuvant chemradiotherapy (hazard ratio: 0.359, 95% confidence interval: 0.253-0.510, P < 0.001 for OS; hazard ratio: 0.522, 95% confidence interval: 0.387-0.705, P < 0.001 for RFS) were confirmed to improve the surgical outcome in patients with abnormal levels of any one of the three postoperative markers, but not in patients with normal levels of the three postoperative markers. In the subgroup of patients with negative lymph node, its improvement of surgical outcome was also significant in patients wit...Continue Reading

Citations

Oct 17, 2019·Cancers·Elisabetta FenocchioMassimo Aglietta
Jun 5, 2020·Cancers·Hongbeom KimJin-Young Jang
Aug 4, 2020·Journal of Cellular and Molecular Medicine·Shunda WangYupei Zhao
Jan 19, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Aleksander SkulimowskiPiotr Hogendorf
May 18, 2021·Frontiers in Cell and Developmental Biology·Zengyu FengChenghong Peng
Aug 31, 2020·Clinical Radiology·R M LahoudM Harisinghani

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