Postoperative serum levels of Endocan are associated with the duration of norepinephrine support after coronary artery bypass surgery

Anaesthesia Critical Care & Pain Medicine
Adrien BougléJulien Amour

Abstract

Cardiopulmonary bypass (CPB) is associated with a systemic inflammatory response and an endothelial dysfunction, whose qualitative assessment appears to be a major issue. Endocan (ESM-1, endothelial cell specific molecule-1) is a protein preferentially expressed by the endothelium and previously associated with prognosis of septic shock or acute respiratory distress syndrome. In this pilot study, we investigated the kinetic of Endocan in planned coronary artery bypass grafting (CABG) surgery with CPB. We conducted an observational, prospective, mono centre study. All adult patients with left systolic ejection fraction>50%, undergoing planned on-pump CABG, were screened for inclusion. A written informed consent was obtained. Measurements and main results Serum Endocan concentrations were respectively 2.4 [2.1-3.0] ng. mL-1, 10.4 [7.4-13.9] ng.mL-1, 5.7 [4.4-8.2] ng.mL-1, and 5.4 [4.1-7.5] ng.mL-1at day 0, day 1, day 3 and day 5. Endocan concentrations increased at day 1, day 3, and day 5 in comparison with preoperative concentration (P<0.001). In the multivariate analysis, age (P=0.002), history of acute coronary syndrome (P=0.024) and the catecholamine-free days at day 28 (P=0.007) were associated to the increase of perioperati...Continue Reading

Citations

Oct 28, 2018·Critical Care : the Official Journal of the Critical Care Forum·Nathalie De Freitas CairesPhilippe Lassalle
Feb 17, 2021·Biomarkers in Medicine·Raffaele SerraGiuseppe F Serraino
May 1, 2021·Current Opinion in Cardiology·Sevket BaltaDimitri P Mikhailidis

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