Postoperative stiffness and adhesion formation around repaired and immobilized Achilles tenotomies are prevented using a model of heat shock protein induction

The Journal of Surgical Research
Claragh HealyDavid Bouchier-Hayes

Abstract

Tendon repair and subsequent immobilization is frequently complicated by postoperative stiffness secondary to inflammation and peritendinous adhesions. Thermal preconditioning is known to reduce inflammation by inducing formation of cytoprotective heat shock proteins. This study evaluates the role of thermal preconditioning following complete division and repair of the Achilles tendon, with subsequent immobilization, mimicking the typical clinical scenario. Twenty-four New Zealand White rabbits were used in the study. The treatment group underwent thermal preconditioning, by elevating their core temperature to 41.5 degrees C for 20 minutes. The Achilles tendon of the hindlimb was divided and repaired 18 hours following thermal preconditioning. The animals were sacrificed following 3 weeks of immobilization. Range of movement of the ankle, tendon gliding, quantity of adhesions, and weight of repaired tendons were assessed. Loss of range of movement at the ankle was significantly less in the treatment group versus controls (P = 0.02). The quantity of adhesions and weight of the repaired tendons were significantly reduced in the treatment group (P = <0.001 and P = 0.005, respectively). Tendon gliding relative to the surrounding so...Continue Reading

References

Nov 1, 1985·The Journal of Hand Surgery·R H GelbermanW H Akeson
Jan 1, 1986·The Journal of Hand Surgery·R H GelbermanW H Akeson
Apr 15, 1974·Journal of Molecular Biology·A TissièresU M Tracy
May 1, 1971·Plastic and Reconstructive Surgery·L D Ketchum
Mar 1, 1982·The Journal of Hand Surgery·R H GelbermanD Amiel
Jan 1, 1993·The Journal of Hand Surgery·E FrykmanB Widenfalk
Aug 1, 1998·Circulation Research·I J Benjamin, D R McMillan
Aug 12, 1998·The Journal of Thoracic and Cardiovascular Surgery·K DoteD M Van Winkle
Jul 10, 1999·The International Journal of Biochemistry & Cell Biology·C C GrayM H Yacoub
Oct 21, 2000·The Journal of Bone and Joint Surgery. British Volume·U KhanD A McGrouther
Jul 2, 2003·Journal of the American College of Surgeons·Paul H McCormickDavid J Bouchier-Hayes

❮ Previous
Next ❯

Citations

Mar 24, 2009·Irish Journal of Medical Science·P MagillK J Mulhall
Feb 27, 2007·The Journal of Hand Surgery, European Volume·C HealyD Bouchier-Hayes
Feb 13, 2016·Journal of Pediatric Orthopedics·Derek S StenquistMininder S Kocher
Apr 20, 2021·Journal of the American Podiatric Medical Association·Yakup AlpayCigdem Elmas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.